Moreira, Natalia M.; Martelli, Lorena S. R.; de Julio, Kiyara I. R.; Zukerman-Schpector, Julio; Opatz, Till; Correa, Arlene G. published the artcile< Copper-Catalyzed One-Pot Synthesis of 3-(N-Heteroarenyl)acrylonitriles through Radical Conjugated Addition of β-Nitrostyrene to Methylazaarenes>, Electric Literature of 5153-70-8, the main research area is heteroarenylacrylonitrile preparation copper catalyst conjugated beta addition nitrostyrene methylazaarene.
A simple procedure for the copper-catalyzed synthesis of 3-(N-heteroaryl)acrylonitriles was developed. Using a combination of Lewis and Bronsted acids, this one-pot procedure undergoes via a radical conjugated addition and dehydration processes, without isolation of any intermediate, affording the acrylonitriles. This diastereoselective approach gave a broad scope of quinazoline derivatives (22 examples) with moderate to good yields and good functional-group tolerance and could be extended to other N-heterocycles such as quinolines and isoquinolines. Based on control experiments, a mechanistic proposal for this new transformation is also presented.
European Journal of Organic Chemistry published new progress about Addition reaction. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics