Chen, Mu-Yi; Pannecoucke, Xavier; Jubault, Philippe; Besset, Tatiana published the artcile< Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature>, Computed Properties of 128-09-6, the main research area is palladium catalyzed stereoselective chlorination acrylamide.
In this Letter, the transition-metal-catalyzed chlorination of alkenes is reported. In the presence of the com. available and inexpensive N-chlorosuccinimide and without additive, the Pd-catalyzed chlorination of acrylamides by C-H bond activation was developed at room temperature under air. Under these mild reaction conditions, the versatility of the methodol. was demonstrated as an array of acrylamides was functionalized to selectively provide the corresponding difficult-to-synthesize chlorinated olefins as a single Z stereoisomer. Mechanistic studies were conducted to get insights into the reaction mechanism, and post-functionalization reactions further demonstrated the synthetic utility of the approach toward the access to high value-added chlorinated compounds
Organic Letters published new progress about Acrylamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Computed Properties of 128-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics