Carmona, Maria; Rodriguez, Ricardo; Passarelli, Vincenzo; Carmona, Daniel published the artcile< Mechanism of the Alkylation of Indoles with Nitrostyrenes Catalyzed by Chiral-at-Metal Complexes>, Electric Literature of 5153-70-8, the main research area is alkylation indole nitrostyrene catalyzed chiral phosphinobenzyl pyridylmethyl amine rhodium; mol structure calculation phosphinobenzyl pyridylmethyl amine rhodium nitrostyrene complex.
Chiral-at-metal rhodium(III) complexes of the formula [Rh(κ4C,N,N’,P-L)A(Solv)][SbF6]n (Solv = A = MeCN, n = 2 (1); Solv = H2O, A = MeCN, n = 2 (2); Solv = MeCN, A = Cl, n = 1 (3); Solv = H2O, A = Cl, n = 1 (4)) catalyze the Friedel-Crafts reaction of trans-β-nitrostyrene and N-methyl-2-methylindole. Complex 4 reacts with trans-β-nitrostyrene, affording [RhCl(κ4C,N,N’,P-L)(trans-β-nitrostyrene)]+ (5). In the presence of N-methyl-2-methylindole, complex 5 reversibly gives a mixture of aci-nitro complexes 6 in high diastereoselectivity which, in turn, evolve to the FC adducts through 1,3-prototropy mediated by a water mol. On the basis of exptl. NMR studies and DFT calculations, a detailed mechanistic pathway for the alkylation reaction is proposed, including an explanation of the origin of the measured enantiomeric ratio.
Organometallics published new progress about Alkylation. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics