Zeng, Yan; Nie, Lifei; Bozorov, Khurshed; Ruzi, Zukela; Song, Buer; Zhao, Jiangyu; Aisa, Haji Akber published the artcile< 2-Substituted tricyclic oxazolo[5,4-d]pyrimidine library: Design, synthesis and cytotoxicity activity>, Formula: C8H4ClF3O2, the main research area is tetrahydrooxazolopyridopyrimidinone preparation cytotoxicity human.
Design, synthetic route and cytotoxicity of a library of 49 newly synthesized tricyclic oxazolo[5,4-d]pyrimidines I [R = Me, Ph, 4-BrC6H4, etc.] was reported. The condensed pyrimidinones were constructed from Et 5-aminooxazole-4-carboxylate building blocks. A tricyclic ring system was built using the naturally occurring mackinazolinone alkaloid with a focus on the mol. diversity at position C-2 of the oxazole ring. Synthesized compounds were evaluated against a panel of human cancer cell lines including MCF-7 (breast), HeLa (cervical) and A549 (lung) in vitro. The results revealed that substitution of halogen-related aromatic fragments at position C-2 of the oxazole ring may serve as promising anticancer drug candidates.
Journal of Heterocyclic Chemistry published new progress about Antitumor agents. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Formula: C8H4ClF3O2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics