Xu, Wen-Ke’s team published research in European Journal of Organic Chemistry in 2021-05-14 | 118-45-6

European Journal of Organic Chemistry published new progress about Addition reaction, stereoselective. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Computed Properties of 118-45-6.

Xu, Wen-Ke; Guo, Jia-Ming; Chen, Zhao-Dan; Si, Chang-Mei; Wei, Bang-Guo published the artcile< Titanium Tetrachloride-Mediated Approach to Access 2-Chloro-2-Substituted Isoindolin-1-ones through the Addition of Alkynes to Acyliminium ions>, Computed Properties of 118-45-6, the main research area is isoindolinone chlorovinyl hydroxyethyl preparation diastereoselective; oxazoloidoindole ring opening addition chlorination terminal alkyne titanium tetrachloride.

An asym. approach to access 2-substituted isoindolin-1-ones I (R1 = R2 = H, MeO; R1 = Cl, R2 = H; R = n-pentyl, cyclopropyl, Ph, 4-FC6H4, 2-MeC6H4, 2-naphthyl, etc.) through TiCl4-mediated addition-chlorination of N,O-acetals II with terminal alkynes RCCH has been developed. A range of substrates were amenable to this transformation and the desired substituted isoindolin-1-ones were obtained in moderate to good yields with moderate diastereoselectivities.

European Journal of Organic Chemistry published new progress about Addition reaction, stereoselective. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Computed Properties of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics