Wang, Di; Li, Qian; Qu, Yidi; Wang, Mengya; Li, Lanzhou; Liu, Yang; Li, Yu published the artcile< The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice>, Application In Synthesis of 6055-19-2, the main research area is cyclophosphamide monohydrate mouse immunosuppression Gloeostereum polysaccharide immunomodulatory activity; Gloeostereum incaratum; cyclophosphamide; immunomodulatory effect; oxidative stress; polysaccharides.
Gloeostereum incarnatum, a precious edible mushroom, displays anti-bacterial and anti-inflammatory activities; however, its immunomodulatory effect has not been studied yet. The present study aimed to investigate whether polysaccharide compositions of G. incarnatum polysaccharides possess immunomodulatory and immuno-enhancing effects in a Cyclophosphamide monohydrate -induced BALB/c mice model. The 28-day GIPS administration at doses of 0.1, 0.3 and 0.9 g/kg remarkably reversed the bodyweight loss, increased the thymic index and promoted T lymphocyte proliferation in CTX-induced immunosuppressed mice. GIPS significantly raised the serum levels of IgA and IgG, promoted the production of interleukins , including IL-2, IL-3 and IL-6, interferons, including interferon IFN-α and IFN-γ, and monocyte chemotactic protein 1 in the spleen, which resulted in accelerating recovery of immunosuppression. Finally, GIPS showed anti-oxidative effects indicated by the increased superoxide dismutase levels in the serum and spleen, and the reduced level of reactive oxygen species in the spleen. The results of the current study demonstrated that GIPS pos. adjusts the immune system, which may serve as a potential immunostimulatory agent.
Experimental and Therapeutic Medicine published new progress about Cell proliferation. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Application In Synthesis of 6055-19-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics