Wan, Zi-juan; Wang, Jin-yuan; Luo, Jun published the artcile< NiCl2-catalyzed radical cross decarboxylative coupling between arylpropiolic acids and cyclic ethers>, Reference of 3240-10-6, the main research area is internal alkene preparation diastereoselective; arylpropiolic acid cyclic ether cross decarboxylative coupling nickel catalyst.
A direct alkenylation of cyclic ethers with arylpropiolic acids was developed for the synthesis of internal alkenes ArCH=CHR [Ar = Ph, 4-CNC6H4, 2-thienyl, etc.; R = tetrahydrofuran-2-yl, 1,3-dioxolan-4-yl, 1,4-dioxan-2-yl] via radical cross decarboxylative coupling process catalyzed by NiCl2 and using DTBP as radical initiator and oxidant. Mechanistic experiments were conducted to determine the nature of the reaction intermediates and a plausible reaction mechanism involving NiCl2-promoted radical process was proposed.
Tetrahedron Letters published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Reference of 3240-10-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics