Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acidOn September 1, 2012 ,《N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Vallin, Karl S. A.; Sterky, Karin J.; Nyman, Eva; Bernstroem, Jenny; From, Rebecka; Linde, Christian; Minidis, Alexander B. E.; Nolting, Andreas; Naerhi, Katja; Santangelo, Ellen M.; Sehgelmeble, Fernando W.; Sohn, Daniel; Strindlund, Jennie; Weigelt, Dirk. The article contains the following contents:
A series of potent antagonists of the ion channel transient receptor potential A1 (TRPA1) was developed by modifying lead structure 16 that was discovered by high-throughput screening. Based on lead compound 16, a SAR was established, showing a narrow region at the nitro-aromatic R1 moiety and at the warhead, while the R2 side had a much wider scope including ureas and carbamates. Compound 16 inhibits Ca2+-activated TRPA1 currents reversibly in whole cell patch clamp experiments, indicating that under in vivo conditions, it does not react covalently, despite its potentially electrophilic ketone. The experimental process involved the reaction of 5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acid)
5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acid
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics