Sugimoto, Yuichi; Shimizu, Atsushi; Kato, Tetsuya; Satoh, Atsushi; Ozaki, Satoshi; Ohta, Hisashi; Okamoto, Osamu published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis, and biological evaluation of indole derivatives as novel nociceptin/orphanin FQ (N/OFQ) receptor antagonists》.Formula: C11H13ClO2 The author mentioned the following in the article:
A novel series of 2-(1,2,4-oxadiazol-5-yl)-1H-indole derivatives as nociceptin/orphanin FQ (N/OFQ) receptor antagonists was discovered. Systematic modification of our original lead by changing the pendant functional groups, linker, heterocyclic core, and basic side chain revealed the structure-activity requirements for this novel template and resulted in the identification of more potent analog with improved potency as compared to the parent compound The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Formula: C11H13ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics