Sang, Dayong; Tian, Juan; Tu, Xiaodong; He, Zhoujun; Yao, Ming published the artcile< Cleavage of Catechol Monoalkyl Ethers by Aluminum Triiodide-Dimethyl Sulfoxide>, SDS of cas: 16766-30-6, the main research area is catechol preparation; monoalkyl ether catechol demethylation aluminum triiodide dimethyl sulfoxide.
Using eugenol and vanillin as model substrates, a practical method is developed for the cleavage o-hydroxyphenyl alkyl ethers. Aluminum oxide iodide (O=AlI), generated in situ from aluminum triiodide and DMSO, is the reactive ether cleaving species. The method is applicable to catechol monoalkyl ethers as well as normal Ph alkyl ethers for the removal of Me, Et, iso-Pr, and benzyl groups. A variety of functional groups such as alkenyl, allyl, amide, cyano, formyl, keto, nitro, and halogen are well tolerated under the optimum conditions. Partial hydrodebromination was observed during the demethylation of 4-bromoguaiacol, and was resolved using excess DMSO as an acid scavenger. This convenient and efficient procedure would be a practical tool for the preparation of catechols.
Synthesis published new progress about C-O bond cleavage. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, SDS of cas: 16766-30-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics