Sahin-Bolukbasi, Serap; Sahin, Neslihan; Tahir, Muhammad Nawaz; Arici, Cengiz; Cevik, Esranur; Gurbuz, Nevin; Ozdemir, Ismail; Cummings, Brian S. published the artcile< Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activity>, SDS of cas: 611-19-8, the main research area is preparation crystal structure silver heterocyclic carbene complex; anticancer activity silver heterocyclic carbene complex.
The authors synthesized four novel unsym. substituted NHC ligands (1a-d) and their Ag(I) complexes (2a-d). All new compounds were characterized using elemental anal., FTIR, 1H NMR, and 13C NMR spectroscopy and X-ray crystallog. The mol. structure of complex 2d was elucidated through single crystal X-ray diffraction analyses. Single crystal structural studies for complex 2d show that the benzene rings (C9-C14) and the central benzimidazole ring system make dihedral angles of 85.65(11)°. The Ag-Cl and Ag-C single bond lengths are 2.3553(7) and 2.096(2) Å, resp. The C-Ag-Cl bond angle is 168.27(7)°. Both salts and complexes were tested for their anti-cancer potential against three human cancer cell lines (DU-145, MCF-7, and MDA-MB-231) and non-cancer cells adipose from mouse (L-929) for 24 h, 48 h and 72 h using the MTT assays. However, the Ag(I)-NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. MDA-MB-231 human breast carcinoma cells were the most sensitive to the Ag(I)-NHC complex displaying IC50 <1 μM all time points. Further, the IC50s for Ag(I)-NHC were higher in non-cancer cells, suggesting that complexes possessed noteworthy selectivity for human cancer cells. Inorganica Chimica Acta published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, SDS of cas: 611-19-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics