Formula: C11H13ClO2On September 15, 2006 ,《Synthesis, biochemical evaluation and rationalization of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α)》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Patel, Chirag H.; Dhanani, Sachin; Owen, Caroline P.; Ahmed, Sabbir. The article contains the following contents:
The preliminary results of the synthesis, biochem. evaluation and rationalization of the inhibitory activity of 1-(arylalkyl)imidazoles 4-RC6H4(CH2)nIm (R = H, F, Cl, Br; n = 1 – 3; Im = 1-imidazolyl) (I) as inhibitors of the two components of the enzyme complex P 45017α, i.e., 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase), are reported. I (R = Br; n = 3) (IC50 = 2.95 μM against 17α-OHase and IC50 = 0.33 μM against lyase) is the most potent compound within the current study and is more potent than ketoconazole (IC50 = 3.76 μM against 17α-OHase and IC50 = 1.66 μM against lyase). Modeling of these compounds suggests that the length of the alkyl chain enhances the interaction between the inhibitor and the area of the active site corresponding to the C(3) area of the steroid backbone, thereby increasing potency. In addition to this study using Ethyl 3-(4-chlorophenyl)propanoate, there are many other studies that have used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2) was used in this study.
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Formula: C11H13ClO2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics