Computed Properties of C9H7ClN2OOn September 15, 2003 ,《Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Myers, Michael R.; He, Wei; Hanney, Barbara; Setzer, Natalie; Maguire, Martin P.; Zulli, Allison; Bilder, Glenda; Galzcinski, Helen; Amin, Dilip; Needle, Saul; Spada, Alfred P.. The article contains the following contents:
Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led to significant improvements in the pharmacokinetic profile of these analogs. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1Computed Properties of C9H7ClN2O)
2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C9H7ClN2O
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics