Manisha; Gupta, Shiv Shankar; Dhiman, Ankit Kumar; Sharma, Upendra published the artcile< Rh(III)-Catalyzed Selective C7 Halogenation of Indolines>, SDS of cas: 128-09-6, the main research area is haloindoline preparation regioselective halogenation halosuccinimide rhodium catalyst; pyrimidylindoline halosuccinimide halogenation rhodium catalyst regioselective.
An efficient Rh-catalyzed catalytic method has been developed for selective C7 halogenation of N-pyrimidyl indolines I (R = H, 5-Ph, 6-F, OCH2Ph, etc., R1 = H, 2-EtO2C, 3-Me, 2-Me, R2 = H) with N-halosuccinimides (halo = chloro, bromo, iodo) to produce the corresponding halides I (R2 = Br, Cl, I) in good to excellent yields. The advantages of this strategy include broad substrate scope and excellent regioselectivity for C7 functionalization of the indolines and feasibility at the gram scale level. Various control experiments have been performed to understand the reaction pathway. Applicability of current methodol. has been demonstrated by indole synthesis and post-transformation of the C7 halogenated indolines into different valuable mols. The reaction is also applicable to the preparation of halogenated carbazoles II (R2 = Br, Cl, I) and tetrahydroquinolines III (R2 = Br, I).
European Journal of Organic Chemistry published new progress about Carbazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics