Lu, Shi-Chao; Chang, Zhi-Xin; Xiao, Yu-Liang; Li, Hong-Shuang published the artcile< Regio- and Stereoselective Synthesis of 2-Hydroxymethyl-1,3-enynes by Rhodium-Catalyzed Decarboxylative C-C Coupling>, Name: 3-(4-Chlorophenyl)propiolic acid, the main research area is hydroxymethyl enyne preparation regioselective diastereoselective; propiolic acid propargyl alc decarboxylative coupling rhodium catalyst.
A regio- and stereoselective protocol for rhodium(I)-catalyzed decarboxylative C-C coupling between propiolic acids R1CCC(O)2H (R1 = CH3, C6H5, 1-benzothiophen-2-yl, etc.) and propargyl alcs. R2R3C(OH)CCR2 (R2R3 = -(CH2)4-, R4 = CH3; R2 = R3 = H, R4 = CH3; R2 = CH3, R3 = C6H5, R4 = H, etc.) has been achieved. This efficient catalytic approach could facilitate the preparation of a diversity of synthetically valuable 2-hydroxymethyl-1,3-enynes (Z)-R2R3C(OH)C(CCR1)=CHR4 with high Z-stereoselectivity. Notably, non-terminal alkynes were smoothly transformed into the target products that show intriguing synthetic utility.
Advanced Synthesis & Catalysis published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Name: 3-(4-Chlorophenyl)propiolic acid.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics