Liu, Min’s team published research in Asian Journal of Organic Chemistry in 2022-08-31 | 118-45-6

Asian Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Synthetic Route of 118-45-6.

Liu, Min; Huang, Min; Li, Wenzhe; Yan, Yingkun; Li, Min; Zhang, Xiaomei published the artcile< Enantioselective Synthesis of Axially Chiral N-Aryl-3-methyleneisoindolin-1-ones>, Synthetic Route of 118-45-6, the main research area is aryl methyleneisoindolinone preparation enantioselective; aniline acetyl benzoic acid phosphoric catalyst.

A chiral phosphoric acid catalyzed enantioselective condensation of 2-acetylbenzoic acid derivatives 2-R-3-R1-4-R2-5-(C(O)CH3)C6HCOOH (R = H, F, Cl, OH; R1 = H, Cl, Me, etc.; R2 = H, F; R1 = R2 = -CH2-CH-CH-CH2-;) with 2-substituted aniline derivatives, 2-R3-4-R4-C6H3NH2 (R3 = t-Bu, i-Pr, I; R4 = H, Br, Ph, etc.) leading to the construction of a series of novel C-N axially chiral N-aryl-3-methylene-isoindolin-1-ones I in moderate to good yields (up to 97%) with generally moderate enantioselectivities (up to 87% ee) was described. In addition, the absolute configuration of product I (R = Cl; R1 = H; R2 = H; R3 = t-Bu; R4 = H) was determined by an X-ray crystal structural anal. Furthermore, one product I was subjected to oxidative cleavage to generate an axially chiral phthalimide.

Asian Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Synthetic Route of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics