《Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors》 was written by La Pietra, Valeria; Sartini, Stefania; Botta, Lorenzo; Antonelli, Alessandro; Ferrari, Silvia Martina; Fallahi, Poupak; Moriconi, Alessio; Coviello, Vito; Quattrini, Luca; Ke, Yi-Yu; Hsing-Pang, Hsieh; Da Settimo, Federico; Novellino, Ettore; La Motta, Concettina; Marinelli, Luciana. Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate And the article was included in European Journal of Medicinal Chemistry on April 25 ,2018. The article conveys some information:
It is now known that “”gain of function”” mutations of RET (REarranged during Transfection) kinase are specific and key oncogenic events in the onset of thyroid gland cancers such as the Medullary Thyroid Carcinoma (MTC). Although a number of RET inhibitors exist and are capable of inhibiting RET variants, in which mutations are outside the enzyme active site, the majority becomes dramatically ineffective when mutations are within the protein active site (V804L and V804M). Pursuing a receptor-based virtual screening against the kinase domain of RET, the authors found that compound (I) is able to inhibit efficiently both wild type and V804L mutant RET. Compound(I) was able to significantly reduce proliferation of both com. available TT cell lines and surgical thyroid tissues obtained from patients with MTC and displayed a suitable drug-like profile, thus standing out as a promising candidate for further development towards the treatment of clin. unresponsive MTC. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate
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