Keivanloo, Ali; Lashkari, Saeed; Sepehri, Saghi; Bakherad, Mohammad; Abbaspour, Sima published the artcile< Ligand-assisted click reaction for the synthesis of new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione and evaluation of their antibacterial activities>, Formula: C7H6Cl2, the main research area is triazole diphenylimidazolidinedione preparation regioselective click reaction antibacterial activity.
The new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione I (R = 3-nitrophenyl, 2-chloro-4-nitrophenyl, 4-chloro-2-nitrophenyl, 4-chloro-3-nitrophenyl), II (R1 = 4-nitrophenyl, 4-chloro-3-nitrophenyl, 2-chloro-4-nitrophenyl) and III (X = H, 2-Cl, 4-Me) were successfully synthesized by copper-catalyzed click reaction in the presence of water-soluble ligand, sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate and copper salt. The click reaction of 5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione and 5,5-diphenyl-1,3-di(prop-2-yn-1-yl)imidazolidine-2,4-dione with aryl azides RN3 or sodium azide and benzyl chloride XC6H4CH2Cl in water produced new 1,2,3-triazoles linked-5,5-diphenylimidazolidine-2,4-dione. The 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate was used as ligand, which enhanced the reactions and reduced the quantity of the toxic copper salt. The in vitro antibacterial activities of the all synthesized compounds I, II and III were screened against the Gram-pos. and Gram-neg. bacteria, by the use of well diffusion method. The results showed that all compounds I, II and III were active against both M. luteus and P. aeruginosa bacteria.
Monatshefte fuer Chemie published new progress about Antibacterial agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Formula: C7H6Cl2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics