The author of 《The synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazole cycle in positions 6, 7 and 8》 were Karpina, V. R.; Kovalenko, S. S.; Kovalenko, S. M.; Zaremba, O. V.; Silin, O. V.; Langer, T.. And the article was published in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2019. SDS of cas: 6313-54-8 The author mentioned the following in the article:
A novel method was developed for the synthesis of 32 analogs of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and biol. assessment was conducted. A convenient scheme for the synthesis of the title compounds started from com. available 2-chloropyridine-3-/4-/5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[1,2,4-oxadiazol-5-yl]pyridines then followed by the hydrazinolysis with an excess of hydrazine hydrate. The process continued via the ester formation with the pyridine ring closure, followed by amide formation. A series of new 2-[6/7/8-(1,2,4-oxadiazol-5-yl)[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields and their structures were proved by the method of 1H NMR spectroscopy. The prognosis and study of their pharmacol. activity were also conducted. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4] triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives2-Chloroisonicotinic acid(cas: 6313-54-8SDS of cas: 6313-54-8) was used in this study.
2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 6313-54-8
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics