Jung, Hyun-Joo; Chen, Zheng; McCarty, Nami published the artcile< Stem-like tumor cells confer drug resistant properties to mantle cell lymphoma>, Recommanded Product: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is chemotherapy resistance mantle cell lymphoma cytotoxic.
We recently identified clonogenic malignant stem cell populations in human mantle cell lymphoma (MCL), a particularly deadly subtype of non-Hodgkin lymphoma (NHL). We discovered that CD45++CD19– MCL cells, which we termed MCL-initiating cells (MCL-ICs), are highly tumorigenic and display self-renewal capacity in vivo; in contrast, CD45++CD19++ MCL cells, which constitute the vast majority of cells within the tumors, show no self-renewal capacity and greatly reduced tumorigenicity. Given the newly appreciated role of cancer-initiating cells in the drug resistance of cancers, it is critical to investigate whether CD45++CD19– MCL-ICs play a role in the drug resistance of human MCL. We discovered that MCL-ICs were more resistant to clin. relevant chemotherapeutic agents, in combination or in a single regimen, compared to CD45++CD19++ cells, and that this drug resistance was largely due to quiescent properties with enriched ABC transporters. In conclusion, designing novel therapies to kill CD45++CD19– MCL-ICs may prevent relapse and increase patient survival.
Leukemia & Lymphoma published new progress about Antitumor agent resistance. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Recommanded Product: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics