Irving, Charles D.; Floreancig, Jack T.; Laulhe, Sebastien published the artcile< Amide Synthesis through the In Situ Generation of Chloro- and Imido-Phosphonium Salts>, Application In Synthesis of 128-09-6, the main research area is amide synthesis in situ generation chlorophosphonium imidophosphonium salt.
We describe a methodol. for the amidation of carboxylic acids by generating phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic, benzylic, and aromatic carboxylic acids can be transformed into their amide counter parts using primary and secondary amines. This functional group interconversion is achieved at room temperature in good to excellent yields. Mechanistic work shows the in situ formation of chloro- and imido-phosphonium salts that react as activating agents for carboxylic acids and generate an acyloxy-phosphonium species.
ACS Omega published new progress about Aliphatic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application In Synthesis of 128-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics