《Synthesis and evaluation of nematicidal activity of compounds derived from norbornadiene》 was published in Journal of the Brazilian Chemical Society in 2020. These research results belong to Gomes, Anni C. S.; Demuner, Antonio J.; Alvarenga, Elson S.; Gondim, Joao P. E.; Fonseca, Andressa R.; Buonicontro, Dalila S.; Pilau, Eduardo J.; Silva, Evandro. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:
Nematode is a major problem in agriculture, the effective way to control this pest is through chem. control, but the efficient mols. present in the market have great toxicity to mammals and birds. Thus, there is a constant demand for the development of new nematicide mols. This study describes the synthesis of norbornadiene derived esters I (R = H, Me, Bn, etc.) and evaluation of their potential activity against Meloidogyne javanica. The esters I presented 50% mortality of the nematodes. The compounds acid II and the ester I (R = Me) caused 96 and 93% mortality of the nematodes, resp. The lethal concentration to kill 50% of the nematodes (LD50) were determined as being 11.8μg mL-1 for the acid II and 99.4μg mL-1 for the ester I (R = Me). According to the results obtained it is believed that polarity seems to be a key factor for the higher activity of compound II compared to structurally similar ester derivatives After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics