Gao, Min; Luo, Yanshu; Xu, Qianlan; Zhao, Yukun; Gong, Xiangnan; Xia, Yuanzhi; Hu, Lin published the artcile< A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles>, Formula: C8H3ClO3, the main research area is oxindole peroxide chiral phase transfer catalyst enantioselective annulation DFT; chiral spirooxindole oxacycle stereoselective preparation; annulation reaction; organocatalysis; oxygen heterocycles; peroxides; umpolung reaction.
A unified catalytic asym. (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.
Angewandte Chemie, International Edition published new progress about C-C bond formation. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Formula: C8H3ClO3.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics