Deguchi, Toru; Xin, Hai-Long; Morimoto, Hiroyuki; Ohshima, Takashi published the artcile< Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides>, Application In Synthesis of 22717-55-1, the main research area is nickel catalyzed alcoholysis unactivated aminoquinoline amide.
Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chem., and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, authors report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcs., affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.
ACS Catalysis published new progress about Alcoholysis. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application In Synthesis of 22717-55-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics