Zhao, Jian; Li, Shuang; Wang, Xinyi; Xu, Gang; Gou, Shaohua published the artcile< Dinuclear Organoruthenium Complexes Exhibiting Antiproliferative Activity through DNA Damage and a Reactive-Oxygen-Species-Mediated Endoplasmic Reticulum Stress Pathway>, Synthetic Route of 67421-02-7, the main research area is dinuclear organoruthenium complex preparation cancer DNA.
Subtle ligand modifications on ruthenium arene complexes can lead to different mechanisms of action and result in significant changes in the anticancer efficacy. Herein, four novel dinuclear ruthenium(II) arene complexes were designed and prepared In vitro tests indicated that complexes 1-3 displayed moderate antiproliferative activity against the tested cancer cells, while the cytotoxicity of complex 4 is superior or comparable to that of cisplatin. Further studies indicated that complexes 1-4 induce cell death through DNA interaction and a reactive-oxygen-species-mediated endoplasmic reticulum (ER) stress pathway, which is the first example of an organometallic ruthenium(II) arene complex to induce ER stress as well as DNA interaction. This kind of dinuclear ruthenium(II) arene complex has unique biol. characteristics and is a promising model for new anticancer drug development.
Inorganic Chemistry published new progress about Antiproliferative agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Synthetic Route of 67421-02-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics