Zeng, Miao; Xue, Jing-Wen; Jiang, Hongwu; Li, Kaiwen; Chen, Yunong; Chen, Zhuqi; Yin, Guochuan published the artcile< Decarboxylative Addition of Propiolic Acids with Indoles to Synthesize Bis(indolyl)methane Derivatives with a Pd(II)/LA Catalyst>, Product Details of C9H5ClO2, the main research area is bisindolylmethane preparation; propiolic acid indole decarboxylative addition palladium Lewis catalyst.
The present work introduces a Pd(II)/LA-catalyzed (LA: Lewis acid) decarboxylative addition reaction for the synthesis of bis(indolyl)methane derivatives The presence of Lewis acid such as Sc(OTf)3 triggered Pd(II)-catalyzed decarboxylative addition of propiolic acids with indoles to offer the bis(indolyl)methane derivatives in moderate to good yields, whereas neither Pd(II) nor Lewis acid alone was active for this synthesis. The catalytic efficiency of Pd(OAc)2 was highly dependent on the Lewis acidity of the added Lewis acid, i.e., a stronger Lewis acid provided a higher yield of the bis(indolyl)methane derivatives Meanwhile, this Pd(II)/LA-catalyzed decarboxylative addition reaction showed good tolerance toward versatile electron-rich or -deficient substituents on the indole skeleton and on the benzyl ring of propiolic acids. The studies on the in situ 1H NMR kinetics of this Pd(II)/Sc(III) catalysis disclosed the formation of a transient vinyl-Pd(II)/Sc(III) intermediate generated by the pyrrole addition to the alkynyl-Pd(II)/Sc(III) species after decarboxylation, which was scarcely observed before.
Journal of Organic Chemistry published new progress about Addition reaction (decarboxylative). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Product Details of C9H5ClO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics