Yu, Hao; Wang, Zhenhua; Wu, Ri; Chen, Xiangfeng; Chan, T.-W. Dominic published the artcile< Water-dispersible pH/thermo dual-responsive microporous polymeric microspheres as adsorbent for dispersive solid-phase extraction of fluoroquinolones from environmental water samples and food samples>, Category: chlorides-buliding-blocks, the main research area is polymeric microsphere liquid chromatog mass spectrometry; dispersive solid phase extraction water dispersibility; Environmental samples; Hydrophilic–hydrophobic transition; Liquid chromatography–mass spectrometry; Polymeric microspheres; Water dispersibility; d-SPE.
Multifunctional polymeric microspheres were prepared using hyper-crosslinking chem. combined with surface-initiated atom transfer radical polymerization The synthesized microspheres exhibited good water dispersibility, a high surface area, and pH/thermo dual-responsiveness. Fluoroquinolones (FQs), which contains a hydrophilic piperazine ring and hydrophobic fluorine atoms, were used as target analytes to assess the performance of the microspheres as a sorbent for dispersive solid-phase extraction (d-SPE). The d-SPE exptl. parameters, including extraction time, amount of microspheres, extraction temperature, and sample solution pH, as well as the desorption conditions, were systematically studied. Coupled with LC-MS/MS, an anal. method for anal. of trace-level FQs in water samples was developed and validated. Under optimal conditions, linearity with correlation coefficients (r) of >0.99 was achieved in the concentration range of 0.02-10 μg L-1. The limits of detection and quantification for the selected FQs were 5.0-6.7 and 12-20 ng L-1, resp. High recovery values (93.1%-97.2%), a high enrichment factor (∼180), and good precision (RSD < 8%, n = 6) were obtained for FQ determination in spiked purified water samples. It was proposed that hydrophilic-hydrophobic transition induced by stretching and shrinking of polymer chains under different pH and temperature conditions offered good control of the surface wettability and altered the extraction behavior. The developed method was validated and was successfully applied to the anal. of FQs in environmental water samples, meat and milk samples. These results demonstrated that the water-dispersible polymeric microspheres have good potential for use in separation and extraction techniques. Journal of Chromatography A published new progress about Adsorbents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Category: chlorides-buliding-blocks.
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