Shand, F. L.; Howard, J. G. published the artcile< Induction in vitro of reversible immunosuppression and inhibition of B cell receptor regeneration by defined metabolites of cyclophosphamide>, Reference of 6055-19-2, the main research area is lymphocyte Ig cyclophosphamide metabolite immunosuppression; receptor lymphocyte cyclophosphamide metabolite immunosuppression.
A number of defined metabolites and derivatives of cyclophosphamide (I) [50-18-0] were compared with the parent compound for their capacity to induce suppression of humoral antibody responses in vivo and in vitro and to inhibit the regeneration of surface Ig (sIg) receptors on B cells subsequent to capping with anti-Ig serum. Both functions were inhibited by exposing spleen cells in vitro to the most active compounds (4-hydroperoxycyclophosphamide [39800-16-3] and phosphoramide mustard [10159-53-2]) in concentrations of ≤10 μg/mL. Although these inhibitory activities were restricted to those mols. with demonstrable alkylating activity, they are nevertheless reversible and not dependent on events leading to cell death. Inhibition with microsomally activated I in vitro rendered splenic B cells hypersusceptible to tolerance induction by levan, although in the absence of this antigen they recovered full responsiveness to it within 7-10 days. Since lethally irradiated mice repopulated with adult bone marrow cells do not regenerate normal responsiveness to polysaccharide antigens in <50-100 days, the rapid recovery by I-treated spleen cells probably involves reversal of suppression in B cells and not renewal from stem cells. The previous proposal that impairment of B cell receptor regeneration by I is causally related to its capacity to promote B cell tolerance induction by thymus-independent antigens is supported. European Journal of Immunology published new progress about Antibodies and Immunoglobulins Role: BIOL (Biological Study). 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Reference of 6055-19-2.
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