Michael, William R.; King, William R.; Wakim, J. M. published the artcile< Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog, and monkey>, Reference of 118-45-6, the main research area is etidronate disodium metabolism; absorption etidronate disodium.
After administration by intragastric cannula, the absorption of disodium etidronate [7414-83-7] (10-20 mg/kg) from the gastrointestinal tract of adult rats, weanling rats, rabbits, monkeys, adult dogs, and young dogs was 3, 10.5, 3.8, 6, 14, and 21% resp. Absorption was primarily from the stomach. I was not metabolized by the rat or dog, and there was virtually no enterohepatic circulation of I in the rat. Approx. half of the absorbed I was excreted in the urine, while the remaining half was deposited in the skeleton. The half-life of I the skeleton of the rat was 12 days.
Toxicology and Applied Pharmacology published new progress about Bone. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Reference of 118-45-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics