Capkova, Katerina; Yoneda, Yoshiyuki; Dickerson, Tobin J.; Janda, Kim D. published the artcile< Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors>, Formula: C8H7ClO2, the main research area is chlorocinnamic acid hydroxamate preparation BoNT A protease inhibitor activity; hydroxamate chlorocinnamic acid preparation structure activity relationship.
Botulinum neurotoxins are the most toxic proteins currently known. Based on a recently identified potent lead structure, 2,4-dichlorocinnamic acid hydroxamate, herein we report on the structure-activity relationship of a series of hydroxamate botulinum neurotoxin A (BoNT/A) protease inhibitors. Among them, 2-bromo-4-chlorocinnamic acid hydroxamate, e.g., I, 2-methyl-4-chlorocinnamic acid hydroxamate, and 2-trifluoromethyl-4-chlorocinnamic acid hydroxamate displayed comparable inhibitory activity to that of the lead structure.
Bioorganic & Medicinal Chemistry Letters published new progress about Biological warfare agents. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Formula: C8H7ClO2.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics