Computed Properties of C6H4Cl2O2SIn 2019 ,《Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety》 appeared in Journal of Enzyme Inhibition and Medicinal Chemistry. The author of the article were Abdel-Maksoud, Mohammed S.; El-Gamal, Mohammed I.; Gamal El-Din, Mahmoud M.; Oh, Chang Hyun. The article conveys some information:
The present work describes the design and synthesis of a novel series of 1,3-diaryl-4-sulfonamidoarylpyrazole derivatives and their in vitro biol. activities. The target compounds were evaluated for antiproliferative activity against NCI-60 cell line panel. Compounds , and showed the highest mean inhibition percentages at 10 μM single-dose testing and were selected to be tested at 5-dose mode. The ICs50 of the most potent compounds were determined over the 60 cell lines. Compound exhibited the strongest activity against different cell lines with IC50 0.33 μM against A498 renal cancer cell line. Compound was tested over a panel of 20 kinases to determine its mol. target(s), and its IC50 values over the most sensitive kinases were defined. In vitro stability and in vivo pharmacokinetic profile of compound was also investigated. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics