Yang, Man; Hua, Jiawei; Wang, Hao; Ma, Tao; Liu, Chengkou; He, Wei; Zhu, Ning; Hu, Yujing; Fang, Zheng; Guo, Kai published the artcile< Photomediated Spirocyclization of N-Benzyl Propiolamide with N-Iodosuccinimide for Access to Azaspiro[4.5]deca-6,9-diene-3,8-dione>, SDS of cas: 3240-10-6, the main research area is iodo azaspirodecadiene dione preparation diastereoselective photochem green chem; benzyl propiolamide iodosuccinimide spirocyclization.
A metal- and oxidant-free route for affording azaspiro[4.5]deca-6,9-diene-3,8-diones (Z) and (E) or (Z) or (E)-I (R1 = H, 6-Me, 7-Br, 7-F, etc.; R2 = Me, Ph, (4-fluorophenyl)sulfonyl, etc.; R3 = Et, Ph, 2-thienyl, etc.) via photomediated iodinated spirocyclization of N-(4-methoxybenzyl)propiolamides R4-4-MeOC6H3CH2N(R2)C(O)CCR3 (R4 = H, 2-Me, 3-Br, 3-F, etc.) has been developed. The reaction underwent a radical addition/ipso-cyclization/dearomatization process at room temperature and successfully constructed C-C and C-I bonds. This green and convenient approach could be generally expanded to produce a range of iodinated spirocyclization products I in moderate to good yields.
Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (propiolamides). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, SDS of cas: 3240-10-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics