Xiong, Wenzhang; Shi, Qiu; Liu, Wenbo H. published the artcile< Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is aryl carboxylic acid chlorobenzoicacid decarboxylative oxygenation; aromatic alc preparation.
Herein, an efficient and practical approach to prepare phenols from benzoic acids via simple organic reagents at room temperature was reported. This approach was compatible with various functional groups and heterocycles and can be easily scaled up. To demonstrate its synthetic utility, bioactive mols. and unsym. hexaarylbenzenes was prepared by leveraging this transformation as strategic steps. Mechanistic investigations suggest that the key migration step involve a free carbocation instead of a radical intermediate. Considering the abundance of benzoic acids and the utility of phenols, it was anticipated that this method will find broad applications in organic synthesis.
Journal of the American Chemical Society published new progress about Aromatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics