Wang, Xi; Wu, Chun-Yan; Li, Yue-Sheng; Dong, Zhi-Bing published the artcile< Three-Component Synthesis of 2-Substituted Thiobenzoazoles Using Tetramethyl Thiuram Monosulfide (TMTM) as Thiocarbonyl Surrogate>, Name: 1-Chloro-2-(chloromethyl)benzene, the main research area is thiobenzoazole preparation tetramethyl thiuram monosulfide thiocarbonyl.
A metal-free synthesis of 2-benzyl/allyl-substituted thiobenzoazoles was developed starting from tetra-Me thiuram monosulfide (TMTM) which served as thiocarbonyl surrogate. By using 2-aminophenols (or 2-aminothiophenols, or 1,2-phenylenediamines) and TMTM as starting materials, 2-mercaptobenzoazoles could be synthesized efficiently. The subsequent C-S bond formation with benzyl/allyl halides gave the final products (2-benzyl/allyl-substituted thiobenzoazoles) with good to excellent yields. The metal-free conditions, inexpensive and easily available starting materials, and broad substrate scope are the advantageous features of this protocol.
European Journal of Organic Chemistry published new progress about Allylic halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Name: 1-Chloro-2-(chloromethyl)benzene.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics