Wang, Cui-Tian; Li, Ming; Ding, Ya-Nan; Wei, Wan-Xu; Zhang, Zhe; Gou, Xue-Ya; Jiao, Rui-Qiang; Wen, Ya-Ting; Liang, Yong-Min published the artcile< Alkylation-Terminated Catellani Reactions by Cyclobutanol C-C Cleavage>, Quality Control of 611-19-8, the main research area is aromatic hydrocarbon preparation; cyclobutanol aryl iodide benzoyloxyamine Catellani reaction; alkyl iodide aryl cyclobutanol Catellani reaction; iodide aryl bromide cyclobutanol Catellani reaction; benzyl chloride aryl iodide cyclobutanol Catellani reaction.
This report describes the first application of a cyclobutanol ring-opening procedure in the Catellani termination reaction, which includes two β-carbon elimination processes. This tandem reaction features mild conditions, high yields, good functional group tolerance, and a broad substrate scope. Meanwhile, four types of electrophiles (N-benzoyloxyamines, e.g., 4-benzoyloxymorpholine, alkyl iodides RR1CHI [R = CH3, (CH2)3CH3, (CH2)4CH3, (CH2)4C(O)2CH3, (CH2)7CH3; R1 = H, CH3], aryl bromides R2C6H4Br [R2 = 2-C(O)2Me, 4-CF3, 4-C(O)2Me], and benzyl chlorides R3C6H4CH2Cl = H, 2-Me, 2-Cl, 3-Me, 4-F, 4-OMe) are quite compatible with this termination reaction for the construction of various types of polysubstituted aromatic hydrocarbons, e.g., I.
Organic Letters published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Quality Control of 611-19-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics