Chang, Chia-Lin; Wu, Chin-Sheng; Wang, Sen-Wen; Wang, Jih-Pyang published the artcile< Synthesis and biological activity of 5-(2'-alkoxycarbonyl substituted phenoxy)furan-2-carboxylic acid derivatives>, SDS of cas: 22717-55-1, the main research area is alkoxycarbonylphenoxyfurancarboxylic acid derivative synthesis biol activity antiallergic antiinflammatory.
A series of 5-(2′-alkoxycarbonyl substituted phenoxy)furan-2-carboxylic acid derivatives were prepared by a facile synthetic route: reaction of Et 5-nitro-2-furoate with the corresponding salicylates. None of the compounds inhibited PMA-induced neutrophil superoxide formation. On the contrary, some carboxylates significantly inhibited fMLP-induced neutrophil degranulation with much greater activity than the pos. control, TFP. One compound also inhibited superoxide formation. Furthermore, another compound strongly inhibited β-glucuronidase and histamine release from mast cells. In particular, this compound was shown to be a novel lead compound with excellent anti-allergic and anti-inflammatory activities. The other compound was shown to be a novel lead compound with excellent anti-inflammatory activity.
Chinese Pharmaceutical Journal (Taipei, Taiwan) published new progress about Allergy. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.
Referemce:
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