Aldous, F. A. B.; Barrass, B. C.; Brewster, K.; Buxton, D. A.; Green, D. M.; Pinder, R. M.; Rich, P.; Skeels, M.; Tutt, K. J. published the artcile< Structure-activity relations in psychotomimetic phenylalkylamines>, Synthetic Route of 53581-86-5, the main research area is psychotomimetic phenylalkylamine; hypothermia behavior phenylalkylamine.
A series of 48 title compounds were tested for the ability to produce hypothermia in rabbits as a qual. screen for psychotomimetic activity. Addnl. tests of the ability to mimic LSD [50-37-3], mescaline [54-04-6], and DOM (2,5-dimethoxy-4-methylamphetamine [15588-95-1] in the cat EEG, as well as behavioral responses in rats, permitted a reliable quant. anal. to be made of structure-activity relations in these drugs. Trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine-HCl (I-HCl) [53581-71-8] produced the full LSD-like response and was about a third as potent as DOM.
Journal of Medicinal Chemistry published new progress about Behavior. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Synthetic Route of 53581-86-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics