Month: September 2022

Morisaki, Yasuhiro;Sawada, Risa;Gon, Masayuki;Chujo, Yoshiki published 《New Types of Planar Chiral [2.2]Paracyclophanes and Construction of One-Handed Double Helices》 in 2016. The article was appeared in 《Chemistry – An Asian Journal》. They have made some progress in their research.Formula: C10H13ClO3 The article mentions the following:

New types of planar chiral (Rp)- and (Sp)-4,7,12,15-tetrasubstituted [2.2]paracyclophanes were synthesized from racemic 4,12-dihydroxy[2.2]paracyclophane as the starting compound Regioselective dibromination and transformation afforded a series of planar chiral (Rp)- and (Sp)-4,7,12,15-tetrasubstituted [2.2]paracyclophanes, which can be used as chiral building blocks. In this study, left- and right-handed double helical structures were constructed via chemoselective Sonogashira-Hagihara coupling. The double helical compounds were excellent circularly polarized luminescence (CPL) emitters with large molar extinction coefficients, good photoluminescence quantum efficiencies, and large CPL dissymmetry factors. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Formula: C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Othman, Dina I. A.;Otsuka, Kota;Takahashi, Shuhei;Selim, Khalid B.;El-Sayed, Magda A.;Tantawy, Atif S.;Okauchi, Tatsuo;Kitamura, Mitsuru published 《Total Synthesis of Eleuthoside A; Application of Rh-Catalyzed Intramolecular Cyclization of Diazonaphthoquinone》 in 2018. The article was appeared in 《Synlett》. They have made some progress in their research.Product Details of 39637-74-6 The article mentions the following:

The first total synthesis of (±)-eleutherol and eleuthoside A, the natural cytotoxic substances extracted from medicinal Indonesian plant, is described. First, the synthesis of (±)-eleutherol has been accomplished in nine steps starting from bromo methoxy aldehyde with the aid of diazo-transfer chem. approach. Second, a metal-catalyzed intramol. cyclization reaction of the corresponding diazonaphthoquinone led to the desired eleuotherol, which served as a precursor to eleuthoside A. Then, several glycosidation routes, using different glucosyl donors, were experimented to reach effective O-glycosidation of eleutherol. The only successful strategy involved Koenigs-Knorr glycosylation using peracetyl glycosyl bromide in the presence of Ag₂O and quinoline. This strategy furnished our desired acetylated glycoside of β-configuration, regioselectively. Finally, deacetylation and successive separation of diastereomers were conducted to give eleuthoside A. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Product Details of 39637-74-6) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peled, Ella;Sosnik, Alejandro published 《Amphiphilic galactomannan nanoparticles trigger the alternative activation of murine macrophages》 in 2021. The article was appeared in 《Journal of Controlled Release》. They have made some progress in their research.Formula: C15H17ClFNO4S The article mentions the following:

Macrophages are highly plastic phagocytic cells that can exist in distinct phenotypes and play key roles in physiol. and pathol. pathways. They can be classically activated to the pro-inflammatory M1 phenotype or alternatively activated to an M2 anti-inflammatory one by various stimuli in the biol. milieu. Different biomaterials polarize macrophages to M1 or M2 phenotypes and emerged as a very promising strategy to modulate their activation and performance. In this work, we investigate the ability of drug-free amphiphilic nanoparticles (hydrodynamic diameter of ∼130 nm) produced by the self-assembly of a graft copolymer of hydrolyzed galactomannan, a natural polysaccharide of galactose and mannose, that was hydrophobized in the side-chain with poly(Me methacrylate) blocks and that can encapsulate hydrophobic drugs, to trigger macrophage polarization. The compatibility and uptake of the nanoparticles are demonstrated in the murine macrophage cell line RAW264.7 by a metabolic assay, confocal laser scanning fluorescence microscopy (CLSFM) and imaging flow cytometry in the absence and the presence of endocytosis inhibitors. Results indicate that they are internalized by both clathrin- and caveolin-mediated endocytosis. The ability of these drug-free nanoparticles to polarize these cells to the M2-like phenotype and to switch an M1 to an M2 phenotype is confirmed by the downregulation of the M1 marker cluster of differentiation 80 (CD80), and upregulation of M2 markers CD163 and CD206, as measured by flow cytometry and CLSFM. In addition, we preliminarily assess the effect of the nanoparticles on wound healing by tracking the closure of an artificial wound of RAW264.7 macrophages in a scratch assay. Findings indicate a faster closure of the wound in the presence of the nanoparticles with respect to untreated cells. Finally, a migration assay utilizing a macrophage/fibroblast co-culture model in vitro demonstrates that M2 polarization increases fibroblast migration by 24-fold with respect to untreated cells. These findings demonstrate the ability of this nanotechnol. platform to interfere and change the macrophages phenotype in vitro and represent robust evidence for the investigation of their therapeutic performance alone or in combination with an encapsulated hydrophobic drug in wound models in vivo. And (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) was used in the research process.

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) can reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs).Formula: C15H17ClFNO4S Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Chen;Li, Fangqiong;Yu, Yan;Huang, Anbang;He, Ping;Lei, Ming;Wang, Jianmin;Huang, Longbin;Liu, Zhenhong;Liu, Jianyu;Wei, Yonggang published 《Design, Synthesis, and Evaluation of a Series of Novel Benzocyclobutene Derivatives as General Anesthetics》 in 2017. The article was appeared in 《Journal of Medicinal Chemistry》. They have made some progress in their research.Category: chlorides-buliding-blocks The article mentions the following:

In the present work, a series of structurally novel benzocyclobutene derivatives were identified as general anesthetics through the loss of righting reflex (LORR) experiment on mice. Our initial efforts found compound 1a with a fused four-membered ring on the 2,3-position of the phenol ring could significantly improve the safety profile. Further SAR study revealed that small hydrogen bond acceptor (HBA) groups are optimal for good ED₅₀ along with much broader therapeutic windows, such as compounds 16b and 17. Present work demonstrates the superiority of this novel benzocyclobutene scaffold. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Category: chlorides-buliding-blocks) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nap, Rikkert J.;Qiao, Baofu;Palmer, Liam C.;Stupp, Samuel I.;Olvera de la Cruz, Monica;Szleifer, Igal published 《Acid-base equilibrium and dielectric environment regulate charge in supramolecular nanofibers》. The research results were published in《Frontiers in Chemistry (Lausanne, Switzerland)》 in 2022.Application In Synthesis of Rubidiumchloride The article conveys some information:

Peptide amphiphiles are a class of mols. that can self-assemble into a variety of supramol. structures, including high-aspect-ratio nanofibers. It is challenging to model and predict the charges in these supramol. nanofibers because the ionization state of the peptides are not fixed but liable to change due to the acid-base equilibrium that is coupled to the structural organization of the peptide amphiphile mols. Here, we have developed a theor. model to describe and predict the amount of charge found on self-assembled peptide amphiphiles as a function of pH and ion concentration In particular, we computed the amount of charge of peptide amphiphiles nanofibers with the sequence C₁₆ – V₂A₂E₂. In our theor. formulation, we consider charge regulation of the carboxylic acid groups, which involves the acid-base chem. equilibrium of the glutamic acid residues and the possibility of ion condensation. The charge regulation is coupled with the local dielec. environment by allowing for a varying dielec. constant that also includes a position-dependent electrostatic solvation energy for the charged species. We find that the charges on the glutamic acid residues of the peptide amphiphile nanofiber are much lower than the same functional group in aqueous solution There is a strong coupling between the charging via the acid-base equilibrium and the local dielec. environment. Our model predicts a much lower degree of deprotonation for a position-dependent relative dielec. constant compared to a constant dielec. background. Furthermore, the shape and size of the electrostatic potential as well as the counterion distribution are quant. and qual. different. These results indicate that an accurate model of peptide amphiphile self-assembly must take into account charge regulation of acidic groups through acid-base equilibrium and ion condensation, as well as coupling to the local dielec. environment. The experimental procedure involved many compounds, such as Rubidiumchloride (cas: 7791-11-9) .

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Application In Synthesis of Rubidiumchloride It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verreault, Dominique;Moreno, Kevin;Merlet, Eric;Adamietz, Frederic;Kauffmann, Brice;Ferrand, Yann;Olivier, Celine;Rodriguez, Vincent published 《Hyper-Rayleigh Scattering as a New Chiroptical Method: Uncovering the Nonlinear Optical Activity of Aromatic Oligoamide Foldamers》. The research results were published in《Journal of the American Chemical Society》 in 2020.Electric Literature of C10H13ClO3 The article conveys some information:

Mol. helixes based on self-organized aromatic oligoamide foldamers have been designed and prepared in their two enantiomeric forms in order to probe their second-order nonlinear chiroptical properties in solution The quinoline oligoamides were rationally functionalized by electron-donating and electron-withdrawing groups to afford a gradual increase of the electronic polarization of the helical architectures. Their hyper-Rayleigh scattering (HRS) responses in solution were accordingly assessed, using either linearly polarized or circularly polarized incident light. Both methods allowed us to observe nonlinear optical activity that was quantified, for the first time for mol. systems, through circular differential scattering intensity ratios. The hyper-Rayleigh optical activity study reveals important charge-transfer differences within the aromatic oligomers, depending on the helix handedness and on the extent of electronic polarization induced by the appended substituents. The origin of the enantiomeric difference is discussed considering both achiral and chiral contributions. Overall, using aromatic oligoamide foldamers as a chiral model, we demonstrate the capabilities of HRS as a complementary chiroptical method, ideally suited for the anal. of various chiral mol. and supramol. systems in solution The reliability and chiral discrimination sensitivity of the method can be further improved through dynamic measurements using standard polarization modulation and heterodyning techniques. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Electric Literature of C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of RubidiumchlorideIn 2021, Geng, Yuxiao;Yang, Bobo;Xiang, Yanrong;Shi, Mingming;Hu, Rongrong;Guo, Chunfeng;Li, Yuefeng;Zou, Jun published 《Preparation and Research of Perovskite Quantum Dots Powder Based on RbCl Doped CsPbBr₃》. 《ChemistrySelect》published the findings. The article contains the following contents:

Researchers have achieved precise control of the size of quantum dots by using the quantum confinement effect. The Rb⁺ and Cs⁺ with similar ionic radii have become a new mechanism for researchers to regulate the emission wavelength of quantum dots. However, there are few studies on the performance of codoped quantum dots with ion at present. By adding a saturated solution of RbCl into an organic solution of CsPbBr₃, quantum dots doped with Rb⁺ and Cs^–were prepared The prepared quantum dots realized adjustable emission spectrum (457-510 nm), stable lattice structure, and good stability under UV light irradiation Therefore, double ion doping is a new method to prepare short-wavelength of quantum dots.Rubidiumchloride (cas: 7791-11-9) were involved in the experimental procedure.

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Reference of Rubidiumchloride It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yang;Weix, Daniel J. published 《Enantioselective Cross-Coupling of meso-Epoxides with Aryl Halides》 in 2015. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Quality Control of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) The article mentions the following:

The first enantioselective cross-electrophile coupling of aryl bromides with meso-epoxides to form trans-β-arylcycloalkanols is presented. The reaction is catalyzed by a combination of (bpy)NiCl₂ and a chiral titanocene under reducing conditions. Yields range from 57 to 99% with 78-95% enantiomeric excess. The 30 examples include a variety of functional groups (ether, ester, ketone, nitrile, ketal, trifluoromethyl, sulfonamide, sulfonate ester), both aryl and vinyl halides, and five- to seven-membered rings. The intermediacy of a carbon radical is strongly suggested by the conversion of cyclooctene monoxide to an aryl [3.3.0]bicyclooctanol. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Quality Control of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Watts, Heath D.;Kubicki, James D.;Kabengi, Nadine published 《Connecting Thermodynamics of Alkali Ion Exchange on the Quartz (101) Surface with Density Functional Theory Calculations》. The research results were published in《Journal of Physical Chemistry A》 in 2022.Application of 7791-11-9 The article conveys some information:

Periodic plane-wave d. functional theory (DFT) calculations were performed on the α-quartz (SiO₂) (101) surface to model exchange of adsorbed Li⁺ and either Na⁺, K⁺, or Rb⁺ in inner- and outer-sphere adsorbed, and aqueous configurations, which are charge-balanced with 2 Cl^–. SiO^– or SiOH groups represented the adsorption surface sites. The SiO^– models included 58 H₂O and 2 H₃O⁺ mols. to approx. an aqueous environment, whereas the SiOH models had 59 H₂O and 1 H₃O⁺ mols. The goal of this work is to calculate the heats of exchange for these alkali ions and to compare the results with those measured by flow microcalorimetry to ascertain the most probable mechanisms for these cations exchanging on the α-quartz (101) surface. Energy minimizations of each alkali ion adsorbed as outer-sphere complexes on SiOH surface sites, and as inner- and outer-sphere complexes on SiO^– surface sites, were used to determine the energy of exchange (ΔE_ex) with Li⁺ for comparison with exptl. determined ΔH_ex values. Here, we present a novel method for calculating ΔE_ex using the difference in energies of geometry-optimized end member models. The aqueous and surface structures produced are similar to those observed exptl. Although the trend for the calculated ΔE_ex values is consistent with those from the heats of exchange measured exptl., the magnitude of our modeled ΔE_ex results is significantly larger than select exptl. data from the literature; we discuss the reasons for this discrepancy herein. The relative energy differences of the various configurations modeled have implications for the measurements of the surface charge via potentiometric titrations due to the more active role of alkali cations in quartz surface chem. that have been previously considered as inert background electrolytes. And Rubidiumchloride (cas: 7791-11-9) was used in the research process.

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Application of 7791-11-9 It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 39637-74-6In 2019, Chantarasriwong, Oraphin;Dorwart, Tanis J.;Morales, Theodore Habarth;Maggio, Stephanie F.;Settle, Aspen L.;Milcarek, Andrew T.;Alpaugh, Mary L.;Theodoraki, Maria A.;Theodorakis, Emmanuel A. published 《Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes》. 《Bioorganic Chemistry》published the findings. The article contains the following contents:

Racemic resolution of (+/-)-MAD28, a representative caged xanthone, was accomplished using (1S, 4R)-(-)-camphanic chloride as the chiral agent. Selective crystallization of the resulting diastereomers in acetonitrile produced, after hydrolysis, the pure enantiomers. Screening of racemic MAD28 and both enantiomers across a broad spectrum of breast cancer cell lines revealed that they: (a) are equipotent in each of the breast cancer subtypes examined; and (b) exhibit a higher degree of cytotoxicity against breast cancer cell lines of basal-like subtype and triple neg. receptor status. The results support the notion that MAD28 and related caged xanthones are promising drug leads against chemoresistant and metastatic cancers.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 SDS of cas: 39637-74-6) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics