Month: September 2022

Miao, Xiu-Juan;Sun, Yong;Ma, Xin-Jun;Xiao, Jing-Lin published 《Asymmetrical semi-exponential potential effect of exciton in strong-coupling alkali halide quantum well》 in . The article was appeared in 《Superlattices and Microstructures》. They have made some progress in their research.Application In Synthesis of Rubidiumchloride The article mentions the following:

Within the framework of the method of Lee-Low-Pines unitary transformations and variations, strong-coupling exciton-longitudinal-optical (LO) phonon interaction in asym. semi-exponential potential quantum wells was investigated. It is shown that the self-trapping energy, effective potential and vibration frequency of the exciton, depends significantly on the parameters of the confined potential, electron-hole distance and electron-hole mass. And Rubidiumchloride (cas: 7791-11-9) was used in the research process.

Rubidium chloride(cas: 7791-11-9) can increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.Application In Synthesis of Rubidiumchloride Pharmaceutical compositions have been used as antidepressants in Europe. It is employed in biochemistry to induce cells to take up DNA.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Han, Lili;Zhang, Hui;Ning, Yayun;Chen, Huanyu;Guo, Chao;Cui, Jinghao;Peng, Guoqiang;Ci, Zhipeng;Jin, Zhiwen published 《Environmentally stable one-dimensional copper halide based ultra-flexible composite film for low-cost X-ray imaging screens》. The research results were published in《Chemical Engineering Journal (Amsterdam, Netherlands)》 in 2022.Safety of Rubidiumchloride The article conveys some information:

Environmentally stable, low cost, large stokes shift, adjustable area and flexibility are basic factors to prepare scintillator films for their com. application. Here, a low cost (∼3 $/g) room-temperature ligand-assisted reprecipitation method is used to synthesize one-dimensional crystal structure based on Rb₂CuX₃ (X = Br, Cl). Rb₂CuBr₃ exhibits quite high mass yield of 90% with high Photoluminescence quantum yield (PLQY) of 59.06%. Importantly, its bright blue emission (90 nm stokes shift) is consistent with the highest optical detection efficiency wavelength range of com. SiPM. Further characterizations point out that such effective blue emission comes from the recombination of excitons rather than the defects or combination of electron-hole pairs. And the existing strong exciton-photon coupling is conducive to the formation of self-trapped excitons (STEs). Finally, uniform and adjustable area Rb₂CuBr₃-polystyrene composite films have been successfully obtained. It’s fascinating that the films exhibit ultra-flexibility (unchanged performance after multiple bending of 400 times) and excellent stability (subtle attenuation after 30 days of storage in a harsh environment). As an X-ray imaging screen, it presents a sensitive scintillation response to X-ray signals with superior linearity with high-quality images. Therefore, our prepared Rb₂CuBr₃ scintillator shows great com. prospects in the field of flexible X-ray detection. The experimental procedure involved many compounds, such as Rubidiumchloride (cas: 7791-11-9) .

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Safety of Rubidiumchloride It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C10H13ClO3《Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents》 was published in 2016. The authors were Gadekar, Pradip K.;Roychowdhury, Abhijit;Kharkar, Prashant S.;Khedkar, Vijay M.;Arkile, Manisha;Manek, Hardik;Sarkar, Dhiman;Sharma, Rajiv;Vijayakumar, V.;Sarveswari, S., and the article was included in《European Journal of Medicinal Chemistry》. The author mentioned the following in the article:

The design, synthesis and antimicrobial evaluation of a novel series of azaspiro analogs I [R = acetyl, 4-(trifluoromethyl)benzoyl, nicotinoyl, etc.] of linezolid were described. Linezolid comprises of a morpholine ring which was known for its metabolism-related liabilities. Therefore, the key modification made in the linezolid structure was the replacement of morpholine moiety with its bioisostere, 2-oxa-6-azaspiro[3.3]heptane. Furthermore, the replacement of N-acetyl terminal of linezolid with various aromatic or aliphatic functionalities was carried out. The title compounds were evaluated against a panel of Gram-pos. and Gram-neg. bacteria and Mycobacterium tuberculosis. Subsequent structure-activity relationship (SAR) studies identified several compounds with mixed antibacterial and antitubercular profiles. Compound I [R = isoxazole-5-carbonyl] (IC₅₀ 0.72, 0.51, 0.88, 0.49 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillussubtilis, resp.) exhibited similar antibacterial profile as linezolid. The N-acetyl derivative I [R = acetyl] was similar to linezolid in antitubercular profile. The use of azaspiro substructure in the medicinal chem. of antibacterial and antitubercular agents was demonstrated.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Synthetic Route of C10H13ClO3) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of Rubidiumchloride《A₂Zn₃P₄S₁₃ (A = Rb and Cs): First Infrared Nonlinear Optical Materials with Mixed Thiophosphate Functional Motifs PS₄ and P₂S₆》 was published in 2022. The authors were Li, Ming-Ze;Jiang, Lin-Tao;Pei, Shao-Min;Liu, Bin-Wen;Jiang, Xiao-Ming;Guo, Guo-Cong, and the article was included in《Journal of Materials Chemistry C: Materials for Optical and Electronic Devices》. The author mentioned the following in the article:

Two new IR NLO compounds, namely Rb₂Zn₃P₄S₁₃ (1) and Cs₂Zn₃P₄S₁₃ (2), have been obtained by introducing d¹⁰ closed-shell cations in an alkali-metal containing thiophosphate system. Compounds 1 and 2 are isostructural and feature a 3D [Zn₃P₄S₁₃] anionic framework. Both compounds exhibit moderate phase-matching SHG intensities at 1910 nm (0.1 x AGS for 1 and 2) and high LIDTs (6.1 x AGS for 1 and 5.2 x AGS for 2). They have wide transparent regions of 2.5-17.7 μm and 2.5-17.0 μm for 1 and 2, resp., which cover the important far-IR atm. window of 3-5 and 8-14 μm for practical applications. Both compounds simultaneously contain two types of NLO-active thiophosphate units (PS₄ and P₂S₆) in their structures, which to the best of our knowledge, is unprecedented in known IR NLO thiophosphates. The NLO efficiencies of 1 and 2 are mainly due to the covalent [Zn₂P₂S₇]^2- framework, in which the contribution of P₂S₆ units is remarkably larger than that of the PS₄ units. This work sheds light on the design of promising IR NLO materials by mixing different thiophosphate functional motifs. And Rubidiumchloride (cas: 7791-11-9) was used in the research process.

Rubidium chloride(cas: 7791-11-9) can increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.Safety of Rubidiumchloride Pharmaceutical compositions have been used as antidepressants in Europe. It is employed in biochemistry to induce cells to take up DNA.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Lin-Tao;Li, Ming-Ze;Jiang, Xiao-Ming;Liu, Bin-Wen;Guo, Guo-Cong published 《AIn₄S₆Cl (A = Rb and Cs) and Pb₅Sn₃Q₁₀Cl₂ (Q = S and Se): quaternary chalcohalides with mixed anionic coordination exhibit photocurrent responses》. The research results were published in《Dalton Transactions》 in 2022.Synthetic Route of ClRb The article conveys some information:

Mixed-anionic compounds have caught considerable attention due to their flexible coordination manners and abundant phys. properties. Four new chalcohalides RbIn₄S₆Cl (1), CsIn₄S₆Cl (2), Pb₅Sn₃S₁₀Cl₂ (3) and Pb₅Sn₃Se₁₀Cl₂ (4) were successfully obtained by the high-temperature halide salt flux method. Compounds 1 and 2 have layered structures that consist of octahedral InS₆ and aliovalent-anionic InS₃Cl units. Compounds 3 and 4 feature 3-D structural frameworks built by [Pb₄SnQ₈Cl₄]^6- and [PbSn₂Q₆]^2- (Q = S and Se) polyhedral chains, in which partial Pb²⁺ cations are coordinated by Q^2- and Cl^– anions. Compounds 1–4 have optical band gaps close to the wavelength range of visible light and exhibit significant photocurrent responses of 28.75 nA cm^-2, 55.12 nA cm^-2, 19.58 mA cm^-2, and 36.12μA cm^-2 with on/off ratios 30.0, 2.5, 15.7 and 2.6, resp., implying their potential for photovoltaic applications. To the best of our knowledge, compound 3 has the largest photocurrent response among all non-oxides. In addition, the activation energies of 1–4 are well below 0.3 eV, which makes these compounds interesting for potential applications in electrochem. devices. This work sheds light on the exploration of promising photocurrent response materials in the mixed-anionic compound system. The experimental procedure involved many compounds, such as Rubidiumchloride (cas: 7791-11-9) .

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Synthetic Route of ClRb It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cinelli, Maris A.;Lee, Kin Sing Stephen published 《Asymmetric Total Synthesis of 19,20-Epoxydocosapentaenoic Acid, a Bioactive Metabolite of Docosahexaenoic Acid》. The research results were published in《Journal of Organic Chemistry》 in 2019.Recommanded Product: (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) The article conveys some information:

In this study, we report the first asym. total synthesis of 19,20-epoxydocosapentaenoic acid I (19,20-EDP), a naturally occurring bioactive cytochrome P 450 metabolite of docosahexaenoic acid, a major constituent of fish oil. Our strategy involves direct asym. epoxidation to produce an enantiopure β-epoxyaldehyde that can be appended to the rest of the skipped polyene core by Wittig condensation. Our route is step-economical and late divergent and could be an appealing method by which to synthesize EDP analogs for biol. studies.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Recommanded Product: (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zdovc, Blaz;Jaklin, Matej;Hribar-Lee, Barbara;Luksic, Miha published 《Influence of Low Molecular Weight Salts on the Viscosity of Aqueous-Buffer Bovine Serum Albumin Solutions》. The research results were published in《Molecules》 in 2022.Application of 7791-11-9 The article conveys some information:

Pharmaceutical design of protein formulations aims at maximum efficiency (protein concentration) and min. viscosity. Therefore, it is important to know the nature of protein-protein interactions and their influence on viscosity. In this work, we investigated the dependence of the viscosity of BSA in an aqueous 20 mM acetate buffer at pH = 4.3 on protein concentration and on temperature (5-45°C). The viscosity of the solution increased with protein concentration and was 230% higher than the viscosity of the protein-free formulation at 160 mg/mL. The viscosity decreased by almost 60% in the temperature range from 5 to 45°C. The agreement of the modified Arrhenius theory with experiment was quant., whereas a hard-sphere model provided only a qual. description of the exptl. results. We also investigated the viscosity of a 100 mg/mL BSA solution as a function of the concentration of added low mol. weight salts (LiCl, NaCl, KCl, RbCl, CsCl, NaBr, NaI) in the range of salt concentrations up to 1.75 mol/L. In addition, the particle size and zeta potential of BSA-salt mixtures were determined for solutions containing 0.5 mol/L salt. The trends with respect to the different anions followed a direct Hofmeister series (Cl^– > Br^– > I^–), whereas for cations in the case of viscosity the indirect Hofmeister series was observed (Li⁺ > Na⁺ > K⁺ > Rb⁺ > Cs⁺), but the values of particle sizes and zeta potential did not show cation-specific effects. Since the protein is pos. charged at pH = 4.3, anions are more attracted to the protein surface and shield its charge, while the interaction with cations is less pronounced. We hypothesize that salt surface charge shielding reduces protein colloidal stability and promotes protein aggregate formation. To complete the study, the researchers used Rubidiumchloride (cas: 7791-11-9) .

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Application of 7791-11-9 It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Noguchi, Hiroki;Takafuji, Makoto;Maurizot, Victor;Huc, Ivan;Ihara, Hirotaka published 《Chiral separation by a terminal chirality triggered P-helical quinoline oligoamide foldamer》. The research results were published in《Journal of Chromatography A》 in 2016.Product Details of 39637-74-6 The article conveys some information:

A P-helical quinoline oligoamide foldamer was grafted on silica and applied as an HPLC stationary phase for chiral separation The P-handedness of the quinoline oligoamide foldamer was induced by a (1S)-camphanyl group, which was introduced at the N-terminus of a tetrameric quinoline oligoamide foldamer (Cmp-Q₄). To immobilize the foldamer on porous silica particles, a trimethoxysilyl group was introduced at the opposing end of the foldamer. Elemental anal. indicated that the amount of foldamer on the silica surface was 0.57 μmol/m². CD and vibrational CD spectra of Cmp-Q₄ and Cmp-Q₄-immobilized silica (Sil-Q₄-Cmp) suggested that the helical structure of Cmp-Q₄ was altered on the silica surface while retaining a chiral structure. The chiral recognition ability of Sil-Q₄-Cmp was evaluated with various aromatic enantiomers. Sil-Q₄-Cmp showed enantio-selectivity for axially chiral mols. (e.g., α_{Trigger’s base} = 1.26 and α_Binaphthol = 1.07). Sil-Q₄-Cmp showed remarkable recognition of helical octameric quinoline oligoamides with isobutoxy and triethylene glycol side chains (α 10.35and 14.98, resp.). In contrast, an (1S)-camphanyl group-immobilized porous silica showed no chiral recognition for any enantiomers tested. To elucidate the chiral separation mechanism of Sil-Q₄-Cmp, thermodn. parameters were calculated using van’t Hoff plots. HPLC results and thermodn. parameters suggested that the chiral recognition of Sil-Q₄-Cmp is based on the helical structure of Cmp-Q₄ and other thermally dependent interactions such as hydrophobic effects associated with aromatic stacking. This work represents the 1st known application of aromatic foldamers in chiral separation The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Product Details of 39637-74-6) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)In 2017, Patil, Nivedita T.;Shashidhar, Mysore S.;Tamboli, Majid I.;Gonnade, Rajesh G. published 《Clues from Crystal Structures Pave the Way to Access Chiral myo-Inositol Derived Versatile Synthons: Resolution of Racemic 4-O-Allyl-myo-Inositol-1,3,5-Orthoesters via Corresponding Dicamphanates by Crystallization》. 《Crystal Growth & Design》published the findings. The article contains the following contents:

Racemic 4-O-allyl-myo-inositol-1,3,5-orthoesters were resolved as the corresponding diastereomeric dicamphanates by crystallization from alc. solvents. Crystals of the two diastereomers of myo-inositol orthoacetate and one diastereomer each of myo-inositol orthoformate and myo-inositol orthobenzoate were obtained in >99% purity, on gram scale. The configuration of all these diastereomers was established by conversion to known chiral myo-inositol derivatives as well as by single crystal structure anal. It is interesting to note that the procedures for the separation of diastereomeric myo-inositol orthoesters could be evolved due to the knowledge of crystal growth and crystal structures of inositol derivatives of comparable mol. structures. Due to the synthetic versatility of myo-inositol orthoesters, the methods described provide rapid and convenient access to a variety of chiral inositol derivatives with high synthetic potential. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Safety of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate《TAK-242 ameliorates olfactory dysfunction in a mouse model of allergic rhinitis by inhibiting neuroinflammation in the olfactory bulb》 was published in 2021. The authors were Lv, Hao;Liu, Peiqiang;Zhou, Fangwei;Gao, Ziang;Fan, Wenjun;Xu, Yu, and the article was included in《International Immunopharmacology》. The author mentioned the following in the article:

Olfactory dysfunction (OD) is a common symptom of allergic rhinitis (AR) that can seriously affect patient quality of life; however, the associated pathogenesis remains unclear. This study aimed to explore the relationship between OD and damage of the olfactory bulb (OB) in allergic rhinitis (AR). The therapeutic potential of TAK-242, a selective TLR4 inhibitor, was evaluated for OD. An AR mouse model was established with ovalbumin (OVA) to test the olfactory function of AR mice using the buried food pellet test (BFPT). Mice with OD were i.p. injected with TAK-242 or 1% DMSO (vehicle). Immunohistochem. was used to detect microglia and astrocyte activation in the OB. TUNNEL staining was performed to detect apoptosis in the OB. Proteins in the TLR4 signaling pathway were detected by Western blot. The level of proinflammatory factor mRNA in the OB was determined by RT-PCR. Neuroinflammation was observed in the OB of the OD group, as evidenced by glial cell activation and increased proinflammatory factor expression. The number of apoptotic cells was significantly increased in the OB of the OD group. The expression of TLR4, MyD88, and p-NF-κBp65 was significantly up-regulated in the OB of the OD group. TAK-242 treatment significantly reduced the level of IL-1β, IL-6, and TNF-α mRNA expression, as well as activation of microglia and astrocytes in the OB tissues. TAK-242 improve olfactory function in AR mice mainly by reducing neuroinflammation and apoptosis in the OB, which may be related to blocking the TLR4/MyD88/NF-κB signaling pathway. To complete the study, the researchers used (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) .

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) can reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs).Quality Control of (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics