Cuadros, Sara team published research on Organic Letters in 2022 | 349-88-2

Computed Properties of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Computed Properties of 349-88-2.

Cuadros, Sara;Rosso, Cristian;Barison, Giorgia;Costa, Paolo;Kurbasic, Marina;Bonchio, Marcella;Prato, Maurizio;Filippini, Giacomo;DellAmico, Luca research published 《 The Photochemical Activity of a Halogen-Bonded Complex Enables the Microfluidic Light-Driven Alkylation of Phenols》, the research content is summarized as follows. A mild light-driven protocol for the direct alkylation of phenols was reported. The process was driven by the photochem. activity of a halogen-bonded complex formed upon complexation of the in-situ generated electron-rich phenolate anion with the α-iodosulfone. The reaction proceeds rapidly (10 min) under microfluidic conditions, delivering a wide variety of ortho-alkylated products (27 examples, up to 97% yield, >20:1 regioselectivity, on a gram scale), including densely functionalized bioactive phenol derivatives

Computed Properties of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Crisenza, Giacomo E. M. team published research on Nature Chemistry in 2021 | 12112-67-3

Recommanded Product: Chloro(1,5-cyclooctadiene)iridium(I) dimer, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, 12112-67-3.

Chlorinated organic compounds are found in nearly every class of biomolecules. 12112-67-3, formula is C16H24Cl2Ir2, Name is Chloro(1,5-cyclooctadiene)iridium(I) dimer. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: Chloro(1,5-cyclooctadiene)iridium(I) dimer.

Crisenza, Giacomo E. M.;Faraone, Adriana;Gandolfo, Eugenio;Mazzarella, Daniele;Melchiorre, Paolo research published 《 Catalytic asymmetric C-C cross-couplings enabled by photoexcitation》, the research content is summarized as follows. Here, authors show how by simply using visible light can divert the established ionic reactivity of a chiral allyl-iridium(III) complex to switch on completely new catalytic functions, enabling mechanistically unrelated radical-based enantioselective pathways. Photoexcitation provides the chiral organometallic intermediate with the ability to activate substrates via an electron-transfer manifold. This redox event unlocks an otherwise inaccessible cross-coupling mechanism, since the resulting iridium(II) center can intercept the generated radicals and underwent a reductive elimination to forge a stereogenic center with high stereoselectivity. This photochem. strategy enables difficult-to-realize enantioselective alkyl-alkyl cross-coupling reactions between allylic alcs. and readily available radical precursors, which are not achievable under thermal activation.

Recommanded Product: Chloro(1,5-cyclooctadiene)iridium(I) dimer, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, 12112-67-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Costa, Leticia D. team published research on New Journal of Chemistry in 2022 | 6334-18-5

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Reference of 6334-18-5

Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Reference of 6334-18-5.

Costa, Leticia D.;Guieu, Samuel;Faustino, Maria do Amparo F.;Tome, Augusto C. research published 《 Straightforward synthesis of thiazolo[5,4-c]isoquinolines from dithiooxamide and 2-halobenzaldehydes》, the research content is summarized as follows. The reaction of dithiooxamide using adequately substituted 2-halobenzaldehydes afforded selectively thiazolo[5,4-c]isoquinolines (TzIQ) I [R = 2-FC6H4, 2,4-di-ClC6H3, 2-O2NC6H4, etc.; R1 = H, Me, Cl, etc.; R2 = H, F, Cl; R3 = H, F, Cl; R4 = H, F, Cl] or mixtures of thiazolo[5,4-d]thiazoles (TzTz) II [R5 = 2-FC6H4, 2-BrC6H4, 2,6-di-BrC6H3, etc.] and thiazolo[5,4-c]isoquinolines (TzIQ). The use of lanthanum(III) triflate as the catalyst favored the formation of TzIQ. The results obtained using a large number of substituted benzaldehydes showed that the nature, number and position of halogen atoms and other substituents on the aldehyde had a great impact on the reaction outcome. The structures of six TzTz and six TzIQ were unveiled by single-crystal X-ray diffraction.

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Reference of 6334-18-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Col, Omer Faruk team published research on Journal of Molecular Structure in | 349-88-2

Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.

Col, Omer Faruk;Bozbey, Irem;Turkmenoglu, Burcin;Uysal, Mehtap research published 《 3(2H)-Pyridazinone derivatives: Synthesis, in-silico studies, structure-activity relationship and in-vitro evaluation for acetylcholinesterase enzyme inhibition》, the research content is summarized as follows. New ten compounds bearing pyridazinone ring I [R = Me, MeO, Cl; R1 = H, F3C, F, Cl] were designed and synthesized as acetylcholinesterase inhibitors. The new derivatives I were acquired via the reaction of propionohydrazides with substituted/nonsubstituted sulfonylchlorides. The structures of the synthesized compounds I were explained using FT-IR, 1H-NMR, 13C-NMR, elemental anal. and HRMS spectra. The inhibition profiles of the synthesized compounds I on AChE were researched by comparing their IC50 and KI values. According to the activity studies, all the compounds I showed significant inhibitory activity against AChE relative to the reference compound Tacrine. The compound I [R = Me, R1 = F] showed the best acetylcholinesterase inhibitory effect with a KI value of 11.61 ± 0.77 nM. For all compounds, I the parameters of the interaction points on the receptor side were determined on the ligand basis with the 4D-QSAR model. The synthesized pyridazinone derivatives, I were screened for their acetylcholinesterase inhibitory potential, and the results determined that among the series, compounds I [R = Me, R1 = F, Cl; R = MeO, R1 = F3C] showed the best inhibition, resp. For anti-Alzheimer activities, compounds I [R = Me, R1 = F, Cl; R = MeO, R1 = F3C] were performed in-silico studies to understand the binding site, binding energy properties in mol. docking.

Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cianni, Lorenzo team published research on Bioorganic & Medicinal Chemistry in 2021 | 2905-24-0

SDS of cas: 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. SDS of cas: 2905-24-0.

Cianni, Lorenzo;Rocho, Fernanda Dos Reis;Bonatto, Vinicius;Martins, Felipe Cardoso Prado;Lameira, Jeronimo;Leitao, Andrei;Montanari, Carlos A.;Shamim, Anwar research published 《 Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L》, the research content is summarized as follows. Human cathepsin B (CatB) is an important biol. target in cancer therapy. In this work, we performed a knowledge-based design approach and the synthesis of a new set of 19 peptide-like nitrile-based cathepsin inhibitors. Reported compounds were assayed against a panel of human cysteine proteases: CatB, CatL, CatK, and CatS. Three compounds (7h, 7i, and 7j, IIII, resp.) displayed nanomolar inhibition of CatB and selectivity over CatK and CatL. The selectivity was achieved by using the combination of a para biphenyl ring at P3, halogenated phenylalanine in P2 and Thr-O-Bz group at P1. Likewise, compounds 7i and 7j showed selective CatB inhibition among the panel of enzymes studied. We have also described a successful example of bioisosteric replacement of the amide bond for a sulfonamide one [7e → 6b, IVV], where we observed an increase in affinity and selectivity for CatB while lowering the compound lipophilicity (ilogP). Our knowledge-based design approach and the resp. structure-activity relationships provide insights into the specific ligand-target interactions for therapeutically relevant cathepsins.

SDS of cas: 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chu, Yunpeng team published research on Organic Letters in 2022 | 104-86-9

COA of Formula: C7H8ClN, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. COA of Formula: C7H8ClN.

Chu, Yunpeng;Wu, Meng;Hu, Fang;Zhou, Panpan;Cao, Zhengqiang;Hui, Xin-Ping research published 《 N-Heterocyclic Carbene-Catalyzed Atroposelective Synthesis of Pyrrolo[3,4-b]pyridines with Configurationally Stable C-N Axial Chirality》, the research content is summarized as follows. The first atroposelective synthesis of pyrrolo[3,4-b]pyridines catalyzed by N-heterocyclic carbene was achieved. A wide range of chiral atropisomers of pyrrolo[3,4-b]pyridines were obtained in high yields with excellent enantioselectivities (96-99% enantiomeric excess). The exptl. results and d. functional theory calculations showed that the C-N axial chirality of the product had high thermal stability.

COA of Formula: C7H8ClN, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chikunova, Elena I. team published research on Green Chemistry in 2022 | 349-88-2

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Synthetic Route of 349-88-2.

Chikunova, Elena I.;Kukushkin, Vadim Yu.;Dubovtsev, Alexey Yu. research published 《 Atom-economic synthesis of β-ketosulfones based on gold-catalyzed highly regioselective hydration of alkynylsulfones》, the research content is summarized as follows. Gold(I)-catalyzed highly regioselective hydration of alkynylsulfones comprised an efficient 100% atom-economic route to β-ketosulfones. The reaction proceeded under mild mercury-free conditions (Ph3PAuNTf2 0.5-5 mol%, THF, rt or 60°C), it demonstrated a high functional group tolerance (more than 30 examples; yields up to 99%), and was easily scaled up. The developed hydration methodol. were successfully integrated into the one-pot syntheses of valuable heterocycles.

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cheng, Bao team published research on European Journal of Medicinal Chemistry in 2022 | 3900-89-8

Name: (2-Chlorophenyl)boronic acid, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Name: (2-Chlorophenyl)boronic acid.

Cheng, Bao;Zhu, Guirong;Meng, Linghua;Wu, Guolin;Chen, Qin;Ma, Shengming research published 《 Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance》, the research content is summarized as follows. Microtubule targeting agents (MTAs) are among the most successful chemotherapeutic drugs, but their efficacy is often limited by the development of multidrug resistance (MDR). Therefore, the development of novel MTAs with the ability to overcome MDR is urgently needed. In this contribution, through modification of the unsym. biaryl compounds, we discovered a novel compound dxy-1-175 with potent anti-proliferative activity against cancer cells. Mechanistic study revealed that dxy-1-175 inhibited tubulin polymerization by interacting with the colchicine-binding site of tubulin, which caused cell cycle arrest at G2/M phase. Based on the predicted binding model of dxy-1-175 with tubulin, a series of new 4-benzoylbiphenyl analogs were designed and synthesized. Among them, the hydrochloride compound 12e with improved solubility and good stability in human liver microsome, exhibited the most potent anti-proliferative activity with IC50 value in the low nanomolar range, and markedly inhibited the growth of breast cancer 4T1 xenograft in vivo. Notably, 12e effectively overcame P-gp-mediated MDR and our preliminary data suggested that 12e may not be a substrate of P-glycoprotein (P-gp). Taken together, our study reveals a novel MTA 12e targeting the colchicine-binding site with potent anticancer activity and the ability to circumvent MDR.

Name: (2-Chlorophenyl)boronic acid, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cheng, Aolin team published research on Angewandte Chemie, International Edition in 2021 | 1878-65-5

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Recommanded Product: 3-Chlorophenylacetic acid

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 3-Chlorophenylacetic acid.

Cheng, Aolin;Zhang, Liangliang;Zhou, Qinghai;Liu, Tao;Cao, Jing;Zhao, Guoqing;Zhang, Kun;Song, Guanshui;Zhao, Baoguo research published 《 Efficient asymmetric biomimetic aldol reaction of glycinates and trifluoromethyl ketones by carbonyl catalysis》, the research content is summarized as follows. The direct asym. aldol reaction of glycinates represents an intriguing and straightforward strategy to make biol. significant chiral β-hydroxy-α-amino-acid derivatives But it is not easy to realize the transformation due to the disruption of the reactive NH2 group of glycinates. Inspired by the enzymic aldol reaction of glycine, we successfully developed an asym. aldol reaction of glycinate, NH2-CH2 CO-O-tert-Bu, and trifluoromethyl ketones with 0.1-0.0033 mol % of chiral N-Me pyridoxal (I) as the catalyst, producing chiral β-trifluoromethyl-β-hydroxy-α-amino-acid esters 6 in 55-82% yields (for the syn-diastereomers) with up to >20:1 dr and 99% ee under very mild conditions. The reaction proceeds via a catalytic cycle similar to the enzymic aldol reaction of glycine. Pyridoxal catalyst I activates both reactants at the same time and brings them together in a specific spatial orientation, accounting for the high efficiency as well as excellent diastereo- and enantioselectivities.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Recommanded Product: 3-Chlorophenylacetic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Yi-Xuan team published research on Organic Letters in 2021 | 2905-24-0

HPLC of Formula: 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. HPLC of Formula: 2905-24-0.

Chen, Yi-Xuan;Wang, Zhu-Jun;Xiao, Jun-An;Chen, Kai;Xiang, Hao-Yue;Yang, Hua research published 《 Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol》, the research content is summarized as follows. Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcs. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant mols. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy.

HPLC of Formula: 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics