Month: September 2022

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Quality Control of 349-88-2.

Fang, Yang;Xu, Dongping;Yu, Yingliang;Tang, Rumeng;Dai, Shuaishuai;Wang, Zhenghua;Zhang, Wu research published 《 Controlled Synthesis of β-Keto Sulfones and Vinyl Sulfones under Electrochemical Oxidation》, the research content is summarized as follows. Selective oxosulfonylation and sulfonylation of alkenes with sulfinates was developed via anodic oxidation in an undivided cell to provide β-keto sulfones I [R¹ = 2-Me, 4-OMe, 3-Cl, etc.; R² = Et, Ph, 2-naphthyl, etc.] and vinyl sulfones II [Ar = Ph, 2-pyridyl, 3-MeC₆H₄, etc.; R³ = Et, Ph, 3-MeC₆H₄, etc.; R⁴ = H, OH] with good to excellent yields in the absence of any transition metal catalyst and oxidants was reported.

Quality Control of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Application of C6H4BrClO2S.

Fang, Yang;Xu, Dongping;Yu, Yingliang;Tang, Rumeng;Dai, Shuaishuai;Wang, Zhenghua;Zhang, Wu research published 《 Controlled Synthesis of β-Keto Sulfones and Vinyl Sulfones under Electrochemical Oxidation》, the research content is summarized as follows. Selective oxosulfonylation and sulfonylation of alkenes with sulfinates was developed via anodic oxidation in an undivided cell to provide β-keto sulfones I [R¹ = 2-Me, 4-OMe, 3-Cl, etc.; R² = Et, Ph, 2-naphthyl, etc.] and vinyl sulfones II [Ar = Ph, 2-pyridyl, 3-MeC₆H₄, etc.; R³ = Et, Ph, 3-MeC₆H₄, etc.; R⁴ = H, OH] with good to excellent yields in the absence of any transition metal catalyst and oxidants was reported.

2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Application of C6H4BrClO2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Computed Properties of 104-86-9.

Fan, Tianyun;Cheng, Yangyang;Wei, Wei;Zeng, Qingxuan;Guo, Xixi;Guo, Zhihao;Li, Yinghong;Zhao, Liping;Shi, Yulong;Zhang, Xintong;Jiang, Jiandong;Wang, Yanxiang;Kong, Weijia;Song, Danqing research published 《 Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3-Kinase/Akt Phosphorylation》, the research content is summarized as follows. Sixty palmatine (PMT) derivatives were synthesized and evaluated for antiplatelet aggregation taking berberine as the lead, and the structure-activity relationship was first systematically described. Among them, compound I showed the best potency in reducing ADP (ADP)-induced platelet aggregation in a dose-dependent manner. It greatly suppressed ADP-induced platelet aggregation, activation, and Akt phosphorylation in vitro and ex vivo after oral administration to mice. It also effectively inhibited carrageenan-induced thrombus formation in the mouse tail and lung, as well as reduced the serum P-selectin level. Compound I might simultaneously bind to protein kinase G to improve vasodilator-stimulated phosphoprotein phosphorylation and bind to phosphatidylinositol 3-kinase to inhibit Akt phosphorylation, which synergically reduced platelet aggregation, thereby achieving antithrombotic efficacy. Therefore, PMT derivatives constituted a novel family of antiplatelet aggregation agents with the advantage of a good safety profile, worthy of further investigation.

Computed Properties of 104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Recommanded Product: 2,3-Dichlorobenzaldehyde.

Fan, Shijie;Yue, Liyan;Wan, Wei;Zhang, Yuanyuan;Zhang, Bidong;Otomo, Chinatsu;Li, Quanfu;Lin, Tingting;Hu, Junchi;Xu, Pan;Zhu, Mingrui;Tao, Hongru;Chen, Zhifeng;Li, Lianchun;Ding, Hong;Yao, Zhiyi;Lu, Junyan;Wen, Yi;Zhang, Naixia;Tan, Minjia;Chen, Kaixian;Xie, Yuli;Otomo, Takanori;Zhou, Bing;Jiang, Hualiang;Dang, Yongjun;Luo, Cheng research published 《 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein》, the research content is summarized as follows. The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein-protein interaction (PPI) target for the intervention of autophagy. Post-translational modifications like acetylation of Lys49 on the LIR-interacting surface could disrupt the interaction, offering an opportunity to design covalent small mols. interfering with the interface. Through screening covalent compounds, we discovered a small mol. modulator of LC3A/B that covalently modifies LC3A/B protein at Lys49. Activity-based protein profiling (ABPP) based evaluations reveal that a derivative mol. DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells. DC-LC3in-D5 compromises LC3B lipidation in vitro and in HeLa cells, leading to deficiency in the formation of autophagic structures and autophagic substrate degradation DC-LC3in-D5 could serve as a powerful tool for autophagy research as well as for therapeutic interventions.

Recommanded Product: 2,3-Dichlorobenzaldehyde, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Computed Properties of 3900-89-8.

Fan, Lingling;Luo, Zhongfu;Yang, Changfei;Guo, Bing;Miao, Jing;Chen, Yang;Tang, Lei;Li, Yong research published 《 Design and synthesis of small molecular 2-aminobenzoxazoles as potential antifungal agents against phytopathogenic fungi》, the research content is summarized as follows. In order to discover novel antifungal agents, three series of simple 2-aminobenzoxazole derivatives I (R = H, NO₂, Ph, 2-benzothienyl, etc.; R¹ = NH₂, acetamidyl, benzenesulfonamido, etc.) were designed, synthesized and evaluated for their antifungal activities against eight phytopathogenic fungi. The in vitro antifungal results showed that most of the target compounds exhibited excellent and broad-spectrum antifungal activities to all the tested fungi. Particularly, the six compounds I (R = Ph, 2-fluorophenyl, 4-fluorophenyl, 3-chlorophenyl, 3,5-dimethylphenyl, 3-thienyl; R¹ = NH₂) displayed the most potent antifungal activity, with EC₅₀ value of 1.48-16.6μg/mL, which were much superior to the pos. control hymexazol. The in vivo study further confirmed that compounds I (R = Ph, 4-fluorophenyl, 3-chlorophenyl, 3,5-dimethylphenyl; R¹ = NH₂) displayed good preventative effect against Botrytis cinerea at the concentration of 100μg/mL. The structure-activity relationships research provides significant reference for the further structural optimization of 2-aminobenzoxazole as potential fungicides.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Computed Properties of 3900-89-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Formula: C6H6BClO2.

Fan, Chi-Hang;Xu, Tianyue;Ke, Zhihai;Yeung, Ying-Yeung research published 《 Autocatalytic aerobic ipso-hydroxylation of arylboronic acid with Hantzsch ester and Hantzsch pyridine》, the research content is summarized as follows. Hantzsch esters were very useful hydrogen and electron donors that was applied in many reactions. After the reactions, aromatic Hantzsch pyridines are generated as the byproducts and their roles were commonly ignored. Herein, the use of Hantzsch pyridine as a promoter to activate Hantzsch ester in the generation of the hydrogen peroxy radical, which is useful for the ipso-hydroxylation of arylboronic acids to give phenols was reported. The reaction does not require an external catalyst or light. The conditions were mild and highly compatible with different functional groups.

Formula: C6H6BClO2, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 12112-67-3, formula is C16H24Cl2Ir2, Name is Chloro(1,5-cyclooctadiene)iridium(I) dimer. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Name: Chloro(1,5-cyclooctadiene)iridium(I) dimer.

Faiges, Jorge;Borras, Carlota;Pastor, Isidro M.;Pamies, Oscar;Besora, Maria;Dieguez, Montserrat research published 《 Density Functional Theory-Inspired Design of Ir/P,S-Catalysts for Asymmetric Hydrogenation of Olefins》, the research content is summarized as follows. In silico-based optimization of Ir/P,S-catalysts for the asym. hydrogenation of unfunctionalized olefins using (E)-1-(but-2-en-2-yl)-4-methoxybenzene as a benchmark olefin has been carried out. DFT calculations revealed that the thioether group has a major role in directing the olefin coordination. This, together with the configuration of the biphenyl phosphite group, has an impact in maximizing the energy gap between the most stable transition states leading to opposite enantiomers. As a result, the optimized catalyst proved to be efficient in the hydrogenation of a range of alkenes with the same substitution pattern and olefin geometry as the benchmark olefin, regardless of the presence of functional groups with different coordination abilities (ee values up to 97%). Appealingly, further modifications at the thioether groups and at the biaryl phosphite moiety allowed the highly enantioselective hydrogenation of olefins with different substitution patterns (e.g., α,β-unsaturated lactones and lactams, 1,1′-disubstituted enol phosphinates, and cyclic β-enamides; ee values up to >99%).

Name: Chloro(1,5-cyclooctadiene)iridium(I) dimer, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, 12112-67-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Related Products of 104-86-9.

Escudero, Julien;Mampuys, Pieter;Mensch, Carl;Bheeter, Charles B.;Vroemans, Robby;Orru, Romano V. A.;Harvey, Jeremy;Maes, Bert U. W. research published 《 Synthesis of Heterocycles via Aerobic Ni-Catalyzed Imidoylation of Aromatic 1,2-Bis-nucleophiles with Isocyanides》, the research content is summarized as follows. O-Phenylene N-substituted iminocarbonates I (R = cyclohexyl, i-Pr, t-Bu, etc.; R¹ = OMe, H; R² = H, OMe, NO₂, CH₂CH₂C=O(OMe), etc.) have been obtained by aerobic Ni-catalyzed reaction of readily available catechols 2-(OH)-3-R¹-5-R²C₆H₂OH and isocyanides RNC. The choice of oxidant and absence of base proved crucial to avoid competitive catechol oxidation into (semi)quinone, leading to degradation The developed protocol is generally applicable on other oxidation-sensitive aromatic 1,2-bis-nucleophiles, generating a variety of important bicyclic heterocycles from readily available building blocks, hitherto only accessible via aerobic noble metal catalysis. Exptl. studies suggest involvement of a Ni^II-catecholate complex, which has been supported by d. functional theory of the catalytic cycle. O-Phenylene N-substituted iminocarbonates demonstrated to be interesting platform mols. providing access to dialkyl N-substituted iminocarbonates RN=C(OR³)₂ (R = cyclohexyl, t-Bu, 4-MeOC₆H₄CH₂CH₂; R³ = n-Bu, Me, Bn, etc.), Di-Bu [2-(4-methoxyphenyl)ethyl]carbonodithioimidate, and N,N’-Dibutyl N”-[2-(4-methoxyphenyl)ethyl]guanidine via reaction with resp. alcs. R³OH, 1-butanethiol, and 1-butanamine. The catechol, which is concomitantly produced as a byproduct in these substitution reactions, can be recycled. When 4-propylcatechol, accessible from pine and clove tree feedstock, is applied, the leaving group is also biorenewable.

Related Products of 104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Formula: C7H4Cl2O.

Enbaraj, E.;Dhineshkumar, E.;Jeyashri, K. R.;Logeshwari, G.;Mohana, V.;Manikandan, H.;Rajathi, V.;Chakkaravarthy, J.;Govindaraju, R.;Seenivasan, M. research published 《 Novel synthesis, spectral characterisation and DFT calculation of (3,4-bis((E)-(substituted-dichlorobenzylidene)amino) phenyl) (phenyl) methanone derivatives》, the research content is summarized as follows. The organic compounds containing (3,4-bis((E)-(2,3-dichlorobenzylidene)amino)phenyl) (phenyl) methanone (1), (3,4-bis((E)-(2,6-dichlorobenzylidene)amino)phenyl)(phenyl) methanone (2) and (3,4-bis((E)-(3,4 dichlorobenzylidene)amino) phenyl)(phenyl) methanone (3) were synthesized in the current study. The synthesized methanone derivatives 1-3 are characterized by elemental anal., mass spectral studies, FT-IR, ¹H & ¹³C NMR. Due to the basis set to derive the optimized geometry, dipole moment, HOMO-LUMO energy, mol. electrostatic potential, Mulliken charge population, and first-order mol. hyperpolarization (β), theor. calculations were carried out using the DFT (B3LYP) strategy with 6-31G(d, p).

Formula: C7H4Cl2O, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Formula: C7H4Cl2O.

Enbaraj, E.;Dhineshkumar, E.;Jeyashri, K. R.;Logeshwari, G.;Devi, V. J. Ramya;Manikandan, H.;Seenivasan, M.;Rajathi, V.;Chakkaravarthy, J.;Govindaraju, R. research published 《 Novel synthesis of NE,N’E-4,4′-sulfonylbis(N-substituted-dichlorobenzylidene)anilines derivative their application biological and DFT studies》, the research content is summarized as follows. The synthesized compounds I (R¹ = H, Cl; R² = H; R³ = H, Cl; R⁴ = H, Cl; R⁵ = H, Cl) were evaluated for their in vitro activity against several microbes. Compound I exhibited potent antibacterial activity with the reference standard ciprofloxacin and fluconazol. In the ground-state, compounds I mol. geometries were determined using the DFT based on B3LYP/6-31G(d,p) and compared to the exptl. results. In addition, compounds I, MEP maps and mol. frontier orbitals were performed, and the results obtained were compatible with the electronic properties.

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Formula: C7H4Cl2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics