Month: September 2022

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Name: (4-Chlorophenyl)methanamine.

Fu, Yiwei;Shi, Haoyu;Lei, Shengshu;Shi, Lei;Li, Hao research published 《 Cu catalyzed [4 + 2] cycloaddition for the synthesis of highly substituted 3-fluoropyridines》, the research content is summarized as follows. A copper catalyzed annulation-aromatization of benzyl trifluoromethyl ketimines with 3-acryloyloxazolidin-2-ones for the synthesis of 3-fluoropyridines I [R = H, 3-Cl, 3-Me, etc.; R¹ = H, 4-Cl, 4-MeO, etc.; R² = 2-oxopyrrolidin-1-yl, 2-oxooxazolidin-3-yl, 2-oxo-3-phenyl-imidazolidin-1-yl, etc.] through double C-F bond cleavages had been developed. In this approach, the annulation occurred between the in situ formed dienes from trifluoromethyl ketimines via the first C-F bond cleavage and 3-acryloyloxazolidin-2-ones. Then the aromatization afforded 3-fluoropyridines I in moderate yields through the second C-F bond cleavage. The 3-fluoropyridine products I [R = R¹ = H; R² = 2-oxooxazolidin-3-yl] could be further hydrolyzed to multi-substituted 3-pyridinecarboxylic acids.

Name: (4-Chlorophenyl)methanamine, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Quality Control of 3900-89-8.

Fu, Xuegang;Yan, Yuting;Sun, Hexin;Li, Siying;Huang, Jianhui research published 《 Natural Product-Inspired Chiral Ligand Design: Aloperine and N-Substituted Aloperines-Induced Pd-Catalyzed Asymmetric Hydroarylation of Ketimines》, the research content is summarized as follows. A naturally occurring alkaloid aloperine was utilized as a chiral skeleton for the development of new ligands/catalysts in asym. synthesis. A number of N-substituted aloperines have been prepared, and a Pd-catalyzed asym. hydroarylation of ketimines using these chiral 1,3-diamine ligands was reported. A range of chiral sulfonyl amides were prepared in high yields and enantioselectivities. The stereoselectivity and structure relationships of aloperines have been studied. In addition, preliminary studies on the desymmetrization of meso-anhydride have also shown that these diamines have good potential in organocatalysis. These discoveries would provide a new future development for natural product-inspired chiral ligand design and developments.

Quality Control of 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Synthetic Route of 349-88-2.

Fu, Jiahui;Cai, Xingxing;Liu, Yihuo;Li, Jinghua;Cheng, Dongping;Xu, Xiaoliang research published 《 Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-Light-Mediated Cyclization of Acryloylbenzamides with Alkylboronic Acids, Arylsulfonyl Hydrazides and Oxime Esters》, the research content is summarized as follows. An efficient visible-light-mediated tandem reaction of acryloylbenzamides with alkylboronic acids, arylsulfonyl hydrazides and oxime esters was developed. The reaction proceeds via radical addition and cyclization to gave various isoquinoline-1,3(2H,4H)-diones I [R¹ = H, 8-Me, 6-MeO, etc.; R² = Me, Et, Ph, etc.; R³ = cyclohexyl, Ts, 3-cyanopropyl, etc.] in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Synthetic Route of 349-88-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 12112-67-3, formula is C16H24Cl2Ir2, Name is Chloro(1,5-cyclooctadiene)iridium(I) dimer. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Application of C16H24Cl2Ir2.

Frost, James R.;Cheong, Choon Boon;Akhtar, Wasim M.;Caputo, Dimitri F. J.;Christensen, Kirsten E.;Stevenson, Neil G.;Donohoe, Timothy J. research published 《 Hydrogen borrowing catalysis using 1° and 2° alcohols: Investigation and scope leading to α and β branched products》, the research content is summarized as follows. The alkylation of a variety of ketones, e.g., 1-cyclopropyl-3-(furan-2-yl)propan-1-one using 1° R¹OH (R¹ = n-Bu, Bn, cyclopropylmethyl, etc.) or 2° alcs. R²R³CHOH (R² = Me, Et; R³ = Et, Ph, thiophen-2-yl, cyclobutyl, etc.; R²R³ = cyclohexyl, 1,4-dioxaspiro[4.5]decan-8-yl, cyclopentyl, etc.) under hydrogen borrowing catalysis is described. Initial research focused on the α-alkylation of cyclopropyl ketones with higher 1° alcs. (i.e. larger than MeOH), leading to the formation of α-branched products, e.g., 1-cyclopropyl-2-(furan-2-ylmethyl)hexan-1-one. The search for addnl. substrates with which to explore this chem. led to discover that di-ortho-substituted aryl ketones were also privileged scaffolds, with Ph^* (C₆Me₅) ketones being the optimal choice. Further investigations revealed that this motif was crucial for alkylation with 2° alcs. forming β-branched products, which also provided an opportunity to study diastereoselective and intramol. hydrogen borrowing processes.

12112-67-3, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, Application of C16H24Cl2Ir2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Formula: C7H4Cl2O.

Fouda, Ahmed M.;Irfan, Ahmad;Al-Sehemi, Abdullah G.;El-Agrody, Ahmed M. research published 《 Synthesis, characterization, anti-proliferative activity and DFT study of 1H-benzo[f]chromene-2-carbothioamide derivatives》, the research content is summarized as follows. Reaction of 7-methoxy-2-naphthol with appropriate aromatic aldehydes and 2-cyano-ethanethioamide provided the corresponding 3-amino-1-aryl-9-methoxy-1H-benzo[f]chromene-2-carbothioamide. The structures of these compounds were established on the basis of IR, ¹H NMR, ¹³C NMR, MS data and elemental anal. Furthermore, the anti-proliferative properties were evaluated against the human cancer cell lines MCF-7, HepG-2 and PC-3 in comparison to the pos. controls Vinblastine and Doxorubicin, employing the viability assay. The obtained results confirmed that some of the tested mols. revealed strong and selective cytotoxic activities against the three cancer cell lines. Moreover, various mol. descriptors, frontier MOs (FMO), Mulliken anal. and electronic properties were studied to probe the biol. activity behavior of the synthesized 1H-benzo[f]chromene-2-carbothioamide derivatives The effect of electron withdrawing groups (EWGs) and electron donating groups (EDGs) were also explored on the structural parameters and electronic nature of compounds The energy gaps, reactivity descriptors values and mol. docking studies exhibited that some 1H-benzo[f]chromene-2-carbothioamide derivatives were active biol. compounds

Formula: C7H4Cl2O, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Electric Literature of 104-86-9.

Finiuk, Nataliya;Klyuchivska, Olga;Mitina, Nataliya;Kuznietsova, Halyna;Volianiuk, Kateryna;Zaichenko, Alexander;Rybalchenko, Volodymyr;Stoika, Rostyslav research published 《 Antineoplastic Activity of Water-Soluble Form of Novel Kinase Inhibitor 1-(4-Chlorobenzyl)-3-chloro-4-(3-trifluoromethylphenylamino)-1H-pyrrole-2,5-dione immobilized on Polymeric Poly(PEGMA-co-DMM) Carrier》, the research content is summarized as follows. The maleimide derivative 1-(4-chlorobenzyl)-3-chloro-4-(3-trifluoromethylphenylamino)-1H-pyrrole-2,5-dione (MI-1) was synthesized as inhibitor of several protein kinases, however, its application is hindered by its poor water solubility In this study, the mechanisms of the antineoplastic action of MI-1 and its MI-1/M5 complex with M5 carrier (poly (PEGMA-co-DMM)) towards human colon carcinoma HCT116 cells were investigated by using the MTT and clonogenic assays, DNA intercalation with methyl green replacement, alk. DNA comet assay, and Western-blot anal. MI-1 compound and its MI-1/M5 complex possessed high toxicity towards colon (HCT116), cervical (HeLa) carcinoma cells and melanoma (SK-MEL-28) cells with GI50 value in a range of 0.75-7.22 μg/mL, and demonstrated high selectivity index (SI ♂ 6.9). The p53 status of colon cancer cells did not affect the sensitivity of these cells to the treatment with MI-1 and its MI-1/M5 complex. M5 polymer possessed low toxicity towards studied cells. The MI-1, MI-1/M5, and M5 only slightly inhibited growth of the pseudo-normal HaCaT and Balb/c 3T3 cell lines (GI50 ♂ 50 μg/mL). The MI-1 and its MI-1/M5 complex induced mitochondria-dependent pathway of apoptosis, damage of the DNA, and morphol. changes in HCT116 cells, and affected the G2/M transition checkpoint. The MI-1 intercalated into the DNA mol., while such capability of MI-1/M5 complex and M5 polymer was much lower. Thus, poly (PEGMA-co-DMM) might be a promising carrier for delivery of the maleimide derivative, MI-1, a novel kinase inhibitor, through improving its solubility in aqueous media and enhancing its antiproliferative action towards human tumor cells. Studies are in progress on the treatment of Nemeth-Kellner lymphoma (NK/Ly)-bearing mice with the MI-1 and MI-1/M5 complex.

104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., Electric Literature of 104-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 12112-67-3, formula is C16H24Cl2Ir2, Name is Chloro(1,5-cyclooctadiene)iridium(I) dimer. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Category: chlorides-buliding-blocks.

Fernando, Nathalie K.;Cairns, Andrew B.;Murray, Claire A.;Thompson, Amber L.;Dickerson, Joshua L.;Garman, Elspeth F.;Ahmed, Nayera;Ratcliff, Laura E.;Regoutz, Anna research published 《 Structural and Electronic Effects of X-ray Irradiation on Prototypical [M(COD)Cl]₂ Catalysts》, the research content is summarized as follows. X-ray characterization techniques are invaluable for probing material characteristics and properties, and have been instrumental in discoveries across materials research. However, there is a current lack of understanding of how X-ray-induced effects manifest in small mol. crystals. This is of particular concern as new X-ray sources with ever-increasing brilliance are developed. In this paper, systematic studies of X-ray-matter interactions are reported on two industrially important catalysts, [Ir(COD)Cl]₂ and [Rh(COD)Cl]₂, exposed to radiation in X-ray diffraction (XRD) and XPS experiments From these complementary techniques, changes to structure, chem. environments, and electronic structure are observed as a function of X-ray exposure, allowing comparisons of stability to be made between the two catalysts. Radiation dose is estimated using recent developments to the RADDOSE-3D software for small mols. and applied to powder XRD and XPS experiments Further insights into the electronic structure of the catalysts and changes occurring as a result of the irradiation are drawn from d. functional theory (DFT). The techniques combined here offer much needed insight into the X-ray-induced effects in transition-metal catalysts and, consequently, their intrinsic stabilities. There is enormous potential to extend the application of these methods to other small mol. systems of scientific or industrial relevance.

12112-67-3, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Computed Properties of 3900-89-8.

Favalli, Nicholas;Bassi, Gabriele;Bianchi, Davide;Scheuermann, Jorg;Neri, Dario research published 《 Large screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation》, the research content is summarized as follows. Progress in DNA-encoded chem. library synthesis and screening crucially relies on the availability of DNA-compatible reactions, which proceed with high yields and excellent purity for a large number of possible building blocks. In the past, exptl. conditions have been presented for the execution of Suzuki and Sonogashira cross-coupling reactions on-DNA. In this article, our aim was to optimize Suzuki and Sonogashira reactions, comparing our results to previously published procedures. We have tested the performance of improved conditions using 606 building blocks (including boronic acids, pinacol boranes and terminal alkynes), achieving >70% conversion for 84% of the tested mols. Moreover, we describe efficient exptl. conditions for the on-DNA synthesis of amide bonds, starting from DNA derivatives carrying a carboxylic acid moiety and 300 primary, secondary and aromatic amines, as amide bonds are frequently found in DNA-encoded chem. libraries thanks to their excellent DNA compatibility.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Computed Properties of 3900-89-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Category: chlorides-buliding-blocks.

Farrukh, Usama B.;Bilal, Aishah;Zahid, Huda;Iqbal, Maheen;Manzoor, Safia;Firdous, Farhat;Furqan, Muhammad;Azeem, Muhammad;Emwas, Abdul-Hamid;Alazmi, Meshari;Gao, Xin;Saleem, Rahman S. Z.;Faisal, Amir research published 《 Synthesis and Evaluation of Novel Carboxamides Capable of Causing Centrosome Declustering and Apoptosis in Breast Cancer Cells》, the research content is summarized as follows. In the current work, synthesis of aryl amides I [R = 1H-pyrrolyl-2-carboxamide, 5-nitrofuranyl, 4-O₂NC₆H₄, etc.; R¹ = Bn, CH₂-2-pyridyl, CH₂-4-ClC₆H₄, etc.] and biol. evaluation of their ability to inhibit centrosome clustering in breast cancer cells (BT-549) was reported. Compound I [R = 5-nitrofuranyl; R¹ = CH(C₆H₅)₂] as a centrosome declustering had potent antiproliferative activity in centrosome amplified BT-549 cells with GI₅₀ value of 1.81±0.19μM (n=2). Treatment of BT-549 cells with I [R = 5-nitrofuranyl; R¹ = CH(C₆H₅)₂] caused centrosome declustering resulted in mitotic arrest due to multipolar spindle formation and misaligned chromosomes which ultimately lead to apoptotic cell death.

104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Related Products of 6334-18-5.

Far, Nesa Lotfi;Rostami, Esmael;Bardajee, Ghasem Rezanejade research published 《 Production, characterization, and application of a novel chitosan-g-maleic anhydride and modified graphene oxide nanocomposite, supported methane sulfonic acid, for efficient synthesis of 1-(benzothiazolylamino) methyl-2-naphtols》, the research content is summarized as follows. An exceptionally productive and sustainable procedure is described in this paper to fabricate 1-(benzothiazolylamino) methyl-2-naphthols using a novel green nanocomposite of chitosan and diethylenetriamine-modified graphene oxide, supported methanesulfonic acid ([email protected].). For the synthesis of the nanocomposite, maleic anhydride was first attached to chitosan, and then, graphene oxide was modified by diethylenetriamine (GO@DETA). Subsequently, nanocomposite was prepared from the reaction of chitosan-g-maleic anhydride and GO@DETA. Finally, methane sulfonic acid was added to the nanocomposite to afford [email protected]. Structural properties of the nanocomposite were explored through various techniques including X-ray diffraction (XRD), thermal gravimetric anal. (TGA), FTIR spectroscopy, SEM (SEM), and energy-dispersive X-ray spectroscopy (EDS). 1-(Benzothiazolylamino) methyl-2-naphthols were efficiently prepared in high to excellent yields through a multicomponent reaction of 2-aminobenzothiazole, aryl aldehydes, and 2-naphthol using [email protected]. nanocomposite under solvent-free conditions. The proposed protocol exhibited superiority over several published protocols due to its nontoxicity and eco-friendly, catalytic ability, short reaction times, generality, efficiency, solvent-free condition, and simple workup.

Related Products of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics