Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Related Products of 6334-18-5.
Han, Min;Zhang, Shi-qi;Cui, Xin;Wang, Qi-wei;Li, Guang-xun;Tang, Zhuo research published 《 Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3)-H Bromination》, the research content is summarized as follows. The enantioselective synthesis of chiral Hantzsch-type 1,4-dihydropyridines (DHPs) I (R = 3-bromophenyl, naphthalen-1-yl, thiophen-2-yl, etc.; R1 = Me, Et, Bn; R2 = Br) frequently contained in pharmaceuticals was described. Readily available sym. 1,4-DHPs I (R2 = H) were used as substrates, and the Me group at the 2- or 6-position of the 1,4-DHP was selectively monobrominated by desymmetrizing enantioselective bromination. The inert C-H bond was converted into a versatile C-Br bond and guaranteed the modification of the chiral 1,4-DHP derivatives I (R2 = Br) with high efficiency. Furthermore, axially chiral 4-aryl pyridines II (R3 = 2-Br, 2,4-(Cl)2, 2,3-(Me)2, etc.; R4 = H, Br) were accessible by central-to-axial chirality conversion.
Related Products of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics