Chloride substituents modify the physical properties of organic compounds in several ways. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Category: chlorides-buliding-blocks.
Geng, Furong;Wu, Shaofeng;Gan, Xinyang;Hou, Wenjuan;Dong, Jianyu;Zhou, Yongbo research published 《 TEMPO mediated oxidative annulation of aryl methyl ketones with amines/ammonium acetate for imidazole synthesis》, the research content is summarized as follows. A facile synthesis of 1H-imidazoles I (R = Ph, pyridin-3-yl, thiophen-2-yl, etc.; R1 = Ph, t-Bu, naphthalen-1-yl, etc.) by direct oxidative annulation of aryl Me ketones (RC(O)CH3) and primary amines R1CH2NH2 has been developed in the presence of TEMPO under weakly acidic conditions. By replacing amines with ammonium acetate, 2H-imidazole skeletons II were achieved for the first time from ketones. Substrates containing various functional groups, such as alkyl, aryl, naphthyl, halogen (F, Cl, Br, I), nitro, trifluoromethyl, sulfonyl ester, furyl, thienyl, and pyridyl groups, were readily transformed into the desired products. The application potential of this method was verified by the scale-up synthesis and Sonogashira coupling functionalization of imidazoles I (R = R1 = phenyl). Mechanistically, the α-TEMPO-enamine adduct may serve as the key reaction intermediate.
Category: chlorides-buliding-blocks, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics