Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: (2-Chlorophenyl)boronic acid.
Gao, Ya;Qin, Wei;Tian, Ming-Qing;Zhao, Xuefei;Hu, Xu-Hong research published 《 Defluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base》, the research content is summarized as follows. Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols.
Recommanded Product: (2-Chlorophenyl)boronic acid, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics