Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Category: chlorides-buliding-blocks.
Farrukh, Usama B.;Bilal, Aishah;Zahid, Huda;Iqbal, Maheen;Manzoor, Safia;Firdous, Farhat;Furqan, Muhammad;Azeem, Muhammad;Emwas, Abdul-Hamid;Alazmi, Meshari;Gao, Xin;Saleem, Rahman S. Z.;Faisal, Amir research published 《 Synthesis and Evaluation of Novel Carboxamides Capable of Causing Centrosome Declustering and Apoptosis in Breast Cancer Cells》, the research content is summarized as follows. In the current work, synthesis of aryl amides I [R = 1H-pyrrolyl-2-carboxamide, 5-nitrofuranyl, 4-O2NC6H4, etc.; R1 = Bn, CH2-2-pyridyl, CH2-4-ClC6H4, etc.] and biol. evaluation of their ability to inhibit centrosome clustering in breast cancer cells (BT-549) was reported. Compound I [R = 5-nitrofuranyl; R1 = CH(C6H5)2] as a centrosome declustering had potent antiproliferative activity in centrosome amplified BT-549 cells with GI50 value of 1.81±0.19μM (n=2). Treatment of BT-549 cells with I [R = 5-nitrofuranyl; R1 = CH(C6H5)2] caused centrosome declustering resulted in mitotic arrest due to multipolar spindle formation and misaligned chromosomes which ultimately lead to apoptotic cell death.
104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics