The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Recommanded Product: 2,3-Dichlorobenzaldehyde.
Fan, Shijie;Yue, Liyan;Wan, Wei;Zhang, Yuanyuan;Zhang, Bidong;Otomo, Chinatsu;Li, Quanfu;Lin, Tingting;Hu, Junchi;Xu, Pan;Zhu, Mingrui;Tao, Hongru;Chen, Zhifeng;Li, Lianchun;Ding, Hong;Yao, Zhiyi;Lu, Junyan;Wen, Yi;Zhang, Naixia;Tan, Minjia;Chen, Kaixian;Xie, Yuli;Otomo, Takanori;Zhou, Bing;Jiang, Hualiang;Dang, Yongjun;Luo, Cheng research published 《 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein》, the research content is summarized as follows. The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein-protein interaction (PPI) target for the intervention of autophagy. Post-translational modifications like acetylation of Lys49 on the LIR-interacting surface could disrupt the interaction, offering an opportunity to design covalent small mols. interfering with the interface. Through screening covalent compounds, we discovered a small mol. modulator of LC3A/B that covalently modifies LC3A/B protein at Lys49. Activity-based protein profiling (ABPP) based evaluations reveal that a derivative mol. DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells. DC-LC3in-D5 compromises LC3B lipidation in vitro and in HeLa cells, leading to deficiency in the formation of autophagic structures and autophagic substrate degradation DC-LC3in-D5 could serve as a powerful tool for autophagy research as well as for therapeutic interventions.
Recommanded Product: 2,3-Dichlorobenzaldehyde, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics