Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. SDS of cas: 349-88-2.
Duan, Wen-Di;Cao, Jing-Yu;Cai, Chao-Yun;Yang, Zhi-Rong;Cui, Jin-Feng;Lan, Tian;Chen, You-Nan;Wang, Jing;Rao, Yong;Huang, Zhi-Shu;Wang, Bo research published 《 Xanthone sulfonamide derivatives-A novel series of α-glucosidase inhibitors with different inhibitory types》, the research content is summarized as follows. In order to discover highly potent α-glucosidase inhibitors, 20 xanthone-benzenesulfonamide derivatives I (R = H, Me, Br, etc.) and II were designed and synthesized. As expected, most of these derivatives exhibited good to excellent inhibitory activities, the IC50 values of these xanthone sulfonamides varied from 0.4 ± 0.05 to 52.2 ± 2.1μM. Especially, compound I (R = OMe) showed the most potent activity (IC50 = 0.4μM), with 111-fold more potent than the pos. control 1-deoxynojirimycin (DNJ), which is a leap compared to authors previous xanthone compound It was noteworthy that these derivatives can be competitive, noncompetitive or uncompetitive inhibitors, while these inhibitory types differed by the alteration of the substituents on the benzene ring of benzenesulfonamide. To give insight into this interesting effect, further docking study was performed, indicating the flexible conformations introduced by the sulfonamide structure affect the binding site and binding mode of these compounds with the enzyme. Furthermore the uncompetitive inhibitors showed significantly stronger binding interactions with the enzyme-substrate complex than the enzyme. Addnl., the competitive inhibitor I (R = NH2) (1μM) exhibited a similar glucose-level decreasing and glucose up-take increasing effect compared to DNJ (5μM), the pos. control in HepG2 cells at five-fold lower concentration, revealing that this compound has promising hypoglycemic effect at the cellular level.
SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics