Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Category: chlorides-buliding-blocks.
Dong, Cuntao;Gao, Wei;Li, Xiaotian;Sun, Susu;Huo, Jingqian;Wang, Yanen;Ren, Da;Zhang, Jinlin;Chen, Lai research published 《 Synthesis of pyrazole-4-carboxamides as potential fungicide candidates》, the research content is summarized as follows. A series of novel pyrazole-4-carboxamides I (Ar = 4-chlorophenyl, furan-2-yl, naphthalen-1-yl, etc.) was rationally designed and synthesized. Preliminary bioassay showed that four compounds I (Ar = 2-fluorophenyl, 4-fluorophenyl (II), 2-methoxyphenyl, thiophen-2-yl) exhibited more than 90% and even completed inhibition against Alternaria solani at 100μg/mL; and compound I (Ar = 4-ethenylphenyl) displayed 100% inhibition against Fusarium oxysporum at the same concentration Moreover, compound (II) exhibited good in vitro fungicidal activity against A. solani with EC50 value of 3.06μg/mL, and it also displayed completed in vivo protective antifungal activity against A. solani on tomato at 10μg/L, as boscalid did. The mol. docking results indicated that compound (II) exhibited the high affinity with SDH protein by H-bond and π-π stacking interactions, which may explain the reasons for its good activities. These data support that compound (II) could be used as a fungicide candidate for further study.
Category: chlorides-buliding-blocks, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics