Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. SDS of cas: 6334-18-5.
Desai, Nisheeth C.;Bhatt, Kandarp;Jadeja, Dharmpalsinh J.;Mehta, Harsh K.;Khedkar, Vijay M.;Sarkar, Dhiman research published 《 Conventional and microwave-assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids》, the research content is summarized as follows. A unique series of 1-(2-(furan-2-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-3-(aryl)-prop-2-en-1-ones I (R = H, 2-OH, 2-NO2) was synthesized utilizing conventional and microwave-assisted techniques. Synthetic compounds were investigated for antitubercular activity against Mycobacterium TB H37Ra and Mycobacterium bovis (M. bovis). Compound I (R = 2-OH) was reported to be the most effective against M. tuberculosis H37Ra (97.69 percent inhibition at 30μg/mL) and M. bovis (97.09 percent inhibition at 30μg/mL). An in silico binding affinity study of mycobacterial enoyl-acyl carrier protein reductase (InhA) reveals the binding mechanism and thermodn. interactions that determine these mol.’s binding affinity. Compound I (R = 2-OH) had a high glide score of -8.991 and low glide energy of -49.893 kcal/mol.
6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., SDS of cas: 6334-18-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics